AP C5

Name: AP C5
Brand: Tocris Bioscience
SKU: 6626
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6626

(1)

COA / SDS

Potent and selective PKG2 inhibitor

Key Product Details

Description:	Potent and selective PKG2 inhibitor
Chemical Name:	4-[4-(1H-Imidazol-1-yl)phenyl]-N-2-propyn-1-yl-2-pyrimidinamine
Purity:	≥98% (HPLC)
Molecular Weight:	275.31

View Full Technical Details for AP C5

Technical Data
Citations / Reviews (1)

Biological Activity for AP C5

AP C5 is a potent and selective protein kinase G type II (PKG2) inhibitor (pIC₅₀ = 7.2). Displays >20-fold selectivity for PKG2 over PKG1 and PKA (pIC₅₀ values are 4.6 and 4.8 for PKG1 and PKA, respectively). Blocks 8-pCPT-cGMP-dependent VASP phosphorylation in intestinal organoids. Also attenuates toxin-stimulated anion secretory responses in mouse intestinal tissue.

Compound Libraries for AP C5

AP C5 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for AP C5

M. Wt	275.31
Formula	C₁₆H₁₃N₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2234272-10-5
PubChem ID	137919866
InChi Key	QKHQFSQJQKGFAA-UHFFFAOYSA-N
Smiles	C#CCNC1=NC(C2=CC=C(N3C=CN=C3)C=C2)=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AP C5

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.53	100
	1eq. HCl	27.53	100

Preparing Stock Solutions for AP C5

The following data is based on the product molecular weight 275.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.63 mL	18.16 mL	36.32 mL
5 mM	0.73 mL	3.63 mL	7.26 mL
10 mM	0.36 mL	1.82 mL	3.63 mL
50 mM	0.07 mL	0.36 mL	0.73 mL

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References for AP C5

References are publications that support the biological activity of the product.

Bijvelds Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors. J.Biol.Chem. 2018 PMID: 29653944