AP 14145 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 6481

Negative allosteric modulator of KCa2 (SK) channels
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Key Product Details

Description

Negative allosteric modulator of KCa2 (SK) channels

View all Ca2+-Activated Potassium Channel Modulators »

Product Description

AP 14145 hydrochloride is a KCa2 (small conductance Ca2+-activated potassium) channel negative allosteric modulator (IC50 = 1.1 μM). Increases the EC50 of Ca2+ on KCa2.3 channels by ~3-fold. Prolongs atrial effective refractory period (AERP) in rats. Reduces atrial fibrillation (AF) duration and prolongs atrial refractoriness without affecting ventricular refractory period in an animal AF model.

Product Specifications

Molecular Weight

398.81

Formula

C18H17F3N4O.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[2-[[(1R)-1-[3-(Trifluoromethyl)phenyl]ethyl]amino]-1H-benzimidazol-7-yl]acetamide hydrochloride

CAS Number

2387505-59-9

InChI Key

KGIUXIYNTCVBST-HNCPQSOCSA-N

SMILES

C[C@H](C1=CC(C(F)(F)F)=CC=C1)NC2=NC3=CC=CC(NC(C)=O)=C3N2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.88 100
Ethanol 39.88 100

Preparing Stock Solutions for AP 14145 hydrochloride

The following data is based on the product molecular weight 398.81

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.51 mL 12.54 mL 25.07 mL
5 mM 0.50 mL 2.51 mL 5.01 mL
10 mM 0.25 mL 1.25 mL 2.51 mL
50 mM 0.05 mL 0.25 mL 0.50 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for AP 14145 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AP 14145 hydrochloride

For research use only

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