ANA 12
Tocris Bioscience, part of Bio-Techne | Catalog # 4781
TrkB receptor antagonist
Product Description
ANA 12 is a TrkB receptor antagonist. Demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively (IC50 values are 45.6 nM and 41.1 μM for the high and low affinity sites respectively). Displays no effect on TrkA and TrkC in an assay of neurite outgrowth. Demonstrates antidepressant properties. Also exhibits anti-seizure effects in an ischemia-induced neonatal seizure model by blocking down-regulation of KCC2.Product Specifications
Molecular Weight
407.49
Formula
C22H21N3O3S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]benzo[b]thiophene-2-carboxamide
CAS Number
219766-25-3
PubChem ID
2799722
InChI Key
TUSCYCAIGRVBMD-UHFFFAOYSA-N
SMILES
O=C(NC4C(NCCCC4)=O)C1=C(NC(C2=CC3=C(C=CC=C3)S2)=O)C=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.15 | 20 |
Preparing Stock Solutions
for ANA 12
The following data is based on the product molecular weight 407.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12.27 mL | 61.35 mL | 122.70 mL |
| 1 mM | 2.45 mL | 12.27 mL | 24.54 mL |
| 2 mM | 1.23 mL | 6.14 mL | 12.27 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Carter Dose-dependent reversal of KCC2 hypofunction and phenobarbital-resistant neonatal seizures by ANA12. Sci.Rep. 2018 PMID: 30097625
- Cazorla Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice. J.Clin.Invest. 2011 PMID: 21505263
Product Specific Notices for ANA 12
For research use only
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