AMT hydrochloride

Name: AMT hydrochloride
Brand: Tocris Bioscience
SKU: 0871

Tocris Bioscience a Bio-Techne Brand

Catalog # 0871

Citations (5)

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Key Product Details

Description:	Potent, selective iNOS inhibitor
Chemical Name:	2-Amino-5,6-dihydro-6-methyl-4H-1,3-thiazine hydrochloride
Molecular Weight:	166.67

View Full Technical Details for AMT hydrochloride

Biological Activity for AMT hydrochloride

AMT hydrochloride is a potent, selective and reversible inhibitor of iNOS (IC₅₀ = 3.6 nM; approximately 30 and 40 times selective over nNOS and eNOS respectively).

Technical Data for AMT hydrochloride

M. Wt	166.67
Formula	C₅H₁₀N₂S.HCl
Storage	Desiccate at +4°C
CAS Number	21463-31-0
PubChem ID	2733501
InChi Key	HVJCRMIQAMEJNM-UHFFFAOYSA-N
Smiles	NC1=NCCC(S1)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AMT hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		10

Preparing Stock Solutions for AMT hydrochloride

The following data is based on the product molecular weight 166.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	60.00 mL	299.99 mL	599.99 mL
0.5 mM	12.00 mL	60.00 mL	120.00 mL
1 mM	6.00 mL	30.00 mL	60.00 mL
5 mM	1.20 mL	6.00 mL	12.00 mL

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References for AMT hydrochloride

References are publications that support the biological activity of the product.

Liao Nitric oxide signaling in stretch-induced apoptosis of neonatal rat cardiomyocytes. FASEB J. 2006 PMID: 16877524
Yu Inhibition of sarcoplasmic reticular function by chronic interleukin-6 exposure via iNOS in adult ventricular myocytes. J.Physiol. 2005 PMID: 15845578
Nakane Novel potent and selective inhibitors of inducible nitric oxide synthase. Mol.Pharmacol. 1995 PMID: 7536889

Citations for AMT hydrochloride (5)

Showing 1 - 5 of 5 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for AMT hydrochloride include:

Lee et al. (2018) Ginsenosides from Korean Red Ginseng ameliorate lung inflammatory responses: inhibition of the MAPKs/NF-κB/c-Fos pathways. J Ginseng Res. 42:476
PMID: 30337808
Wong et al. (2017) Role of inducible nitric oxide synthase in endothelium-independent relaxation to RLX in rat aorta. Br J Pharmacol. 174:718
PMID: 28138957
Lee et al. (2016) Inhibition of Lung Inflammation by Acanthopanax divaricatus var. Albeofructus and Its Constituents. PLoS One. 24:67
PMID: 26759704
Messlinger et al. (2000) Involvement of nitric oxide in the modulation of dural arterial blood flow in the rat. Br J Pharmacol. 129:1397
PMID: 10742295
Zanardo et al. (1997) Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils. Proc Natl Acad Sci U S A. 94:14111
PMID: 9391161

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