AMT hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0871
Potent, selective iNOS inhibitor
Product Description
AMT hydrochloride is a potent, selective and reversible inhibitor of iNOS (IC50 = 3.6 nM; approximately 30 and 40 times selective over nNOS and eNOS respectively).Product Specifications
Molecular Weight
166.67
Formula
C5H10N2S.HCl
Storage
Desiccate at +4°C
Chemical Name
2-Amino-5,6-dihydro-6-methyl-4H-1,3-thiazine hydrochloride
CAS Number
21463-31-0
PubChem ID
2733501
InChI Key
HVJCRMIQAMEJNM-UHFFFAOYSA-N
SMILES
NC1=NCCC(S1)C.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 10 |
Preparing Stock Solutions
for AMT hydrochloride
The following data is based on the product molecular weight 166.67
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 60.00 mL | 299.99 mL | 599.99 mL |
| 0.5 mM | 12.00 mL | 60.00 mL | 120.00 mL |
| 1 mM | 6.00 mL | 30.00 mL | 60.00 mL |
| 5 mM | 1.20 mL | 6.00 mL | 12.00 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nakane Novel potent and selective inhibitors of inducible nitric oxide synthase. Mol.Pharmacol. 1995 PMID: 7536889
- Yu Inhibition of sarcoplasmic reticular function by chronic interleukin-6 exposure via iNOS in adult ventricular myocytes. J.Physiol. 2005 PMID: 15845578
- Liao Nitric oxide signaling in stretch-induced apoptosis of neonatal rat cardiomyocytes. FASEB J. 2006 PMID: 16877524
Product Specific Notices for AMT hydrochloride
For research use only
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