AMN 082 dihydrochloride

Name: AMN 082 dihydrochloride
Brand: Tocris Bioscience
SKU: 2385
Price: 144 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 2385

Citations (3)

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Key Product Details

Description:	Selective mGlu₇ agonist
Chemical Name:	N,N'-Bis(diphenylmethyl)-1,2-ethanediamine dihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	465.45

View Full Technical Details for AMN 082 dihydrochloride

Biological Activity for AMN 082 dihydrochloride

AMN 082 dihydrochloride is a the first selective mGlu₇ agonist. Potently inhibits cAMP accumulation and stimulates GTPγS binding in recombinant cells and on membranes expressing mGlu₇ (EC₅₀ = 64 - 290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 μM. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats.

View important information regarding the usage of AMN 082 dihydrochloride.

Compound Libraries for AMN 082 dihydrochloride

AMN 082 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AMN 082 dihydrochloride

M. Wt	465.45
Formula	C₂₈H₂₈N₂.2HCl
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	97075-46-2
PubChem ID	11698390
InChi Key	YRQCDCNQANSUPB-UHFFFAOYSA-N
Smiles	Cl.Cl.C(CNC(C1=CC=CC=C1)C1=CC=CC=C1)NC(C1=CC=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AMN 082 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	46.55	100
	water	0.93	2 with gentle warming

Preparing Stock Solutions for AMN 082 dihydrochloride

The following data is based on the product molecular weight 465.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.74 mL	21.48 mL
5 mM	0.43 mL	2.15 mL	4.30 mL
10 mM	0.21 mL	1.07 mL	2.15 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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References for AMN 082 dihydrochloride

References are publications that support the biological activity of the product.

Greco Metabotropic glutamate 7 receptor subtype modulates motor symptoms in rodent models of Parkinson's disease. J.Pharmacol.Exp.Ther. 2010 PMID: 19940105
Flor AMN082, the first selective mGluR7 agonist: activation of receptor signaling via an allosteric site in the transmembrane domain modulates stress parameters in vivo. Neuropharmacology
Mitsukawa A selective metabotropic glutamate receptor 7 agonist: Activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Proc.Natl.Acad.Sci.USA

Citations for AMN 082 dihydrochloride (3)

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Citations are publications that use Bio-Techne products. Selected citations for AMN 082 dihydrochloride include:

Shao et al. (2019) Activating metabotropic glutamate receptor-7 attenuates visceral hypersensitivity in neonatal maternally separated rats. Int J Mol Med. 43:761
PMID: 30569115
Jantas et al. (2018) New evidences for a role of mGluR7 in astrocyte survival: Possible implications for neuroprotection. Neuropharmacology. 141:223
PMID: 30170084
Broadstock et al. (2012) Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulata. Br J Pharmacol. 165:1034
PMID: 21627638

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Product Documents for AMN 082 dihydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.