Amlodipine besylate is a L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca²⁺-induced contractions in depolarized rat aorta (IC₅₀ = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC₅₀ = 25 μM).

Product Specifications

Molecular Weight

567.05

Formula

C₂₀H₂₅ClN₂O₅.C₆H₆O₃S

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzenesulfonate

CAS Number

111470-99-6

PubChem ID

60496

InChI Key

ZPBWCRDSRKPIDG-UHFFFAOYSA-N

SMILES

OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C1C1=CC=CC=C1Cl)C(=O)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	56.7	100

Preparing Stock Solutions for Amlodipine besylate

The following data is based on the product molecular weight 567.05

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.76 mL	8.82 mL	17.64 mL
5 mM	0.35 mL	1.76 mL	3.53 mL
10 mM	0.18 mL	0.88 mL	1.76 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Yoshida Antiproliferative effect of Ca²⁺ channel blockers on human epidermoid carcinoma A431 cells. Eur.J.Pharmacol. 2003 PMID: 12860469
Toba Calcium channel blockades exhibit anti-inflammatory and antioxidative effects by augmentation of endothelial nitric oxide synthase and the inhibition of angiotensin converting enzyme in the NG-nitro-L-arginine methyl ester-induced hype Hypertens.Res. 2005 PMID: 16392774
Burges Calcium channel blocking properties of amlod. in vascular smooth muscle and cardiac muscle in vitro: evidence for voltage modulation of vascular dihydropyridine receptors. J.Cardiovasc.Pharmacol. 1987 PMID: 2434785

Amlodipine besylate

Tocris Bioscience, part of Bio-Techne | Catalog # 2571

Key Product Details

Description

Alternative Names

View all Cav1.x Channel Blockers »

Product Description