AMG PERK 44
Tocris Bioscience, part of Bio-Techne | Catalog # 5517
Potent and selective PERK inhibitor; orally bioavailable
Key Product Details
Description
Potent and selective PERK inhibitor; orally bioavailable
Product Description
AMG PERK 44 is a potent and selective PERK inhibitor (IC50 = 6 nM). Exhibits >160-fold selectivity for PERK over B-Raf and GCN2, as well as a panel of 387 other kinases. Orally bioavailable.Licensing Information
By permission of the authorsProduct Specifications
Molecular Weight
561.07
Formula
C34H28N4O2.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[2-Amino-4-methyl-3-(2-methyl-6-quinolinyl)benzoyl]-1,2-dihydro-1-methyl-2,5-diphenyl-3H-pyrazol-3-one hydrochloride
CAS Number
1883548-84-2
PubChem ID
121513867
InChI Key
RNAKBTDDCHJCMT-UHFFFAOYSA-N
SMILES
CC2=NC1=CC=C(C3=C(N)C(C(C4=C(C5=CC=CC=C5)N(C)N(C6=CC=CC=C6)C4=O)=O)=CC=C3C)C=C1C=C2.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.22 | 20 |
Preparing Stock Solutions
for AMG PERK 44
The following data is based on the product molecular weight 561.07
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 8.91 mL | 44.56 mL | 89.12 mL |
| 1 mM | 1.78 mL | 8.91 mL | 17.82 mL |
| 2 mM | 0.89 mL | 4.46 mL | 8.91 mL |
| 10 mM | 0.18 mL | 0.89 mL | 1.78 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Smith Discovery of 1H-pyrazol-3(2H)-ones as potent and selective inhibitors of protein kinase R-like endoplasmic reticulum kinase (PERK). J.Med.Chem. 2015 PMID: 25587754
Product Specific Notices for AMG PERK 44
For research use only
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