Ambrisentan
Tocris Bioscience, part of Bio-Techne | Catalog # 5828
Selective ETA antagonist
Key Product Details
Description
Selective ETA antagonist
Product Description
Ambrisentan is a selective endothelin receptor ETA antagonist. Displays approximately 200-fold selectivity for ETA over ETB (Ki values are 1 nM and 195 nM for respectively). Prevents endothelin-induced sudden death in rats.Product Specifications
Molecular Weight
378.42
Formula
C22H22N2O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(αS)-α-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenylbenzenepropanoic acid
CAS Number
177036-94-1
PubChem ID
6918493
InChI Key
OUJTZYPIHDYQMC-LJQANCHMSA-N
SMILES
CC1=CC(C)=NC(O[C@H](C(O)=O)C(C2=CC=CC=C2)(OC)C3=CC=CC=C3)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.84 | 100 | |
| Ethanol | 37.84 | 100 |
Preparing Stock Solutions
for Ambrisentan
The following data is based on the product molecular weight 378.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.64 mL | 13.21 mL | 26.43 mL |
| 5 mM | 0.53 mL | 2.64 mL | 5.29 mL |
| 10 mM | 0.26 mL | 1.32 mL | 2.64 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Vatter & Seifert Ambrisentan, a non-peptide endothelin receptor antagonist. Cardiovasc.Drug Rev. 2006 PMID: 16939634
- Riechers Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists. J.Med.Chem. 1996 PMID: 8667356
Product Specific Notices for Ambrisentan
For research use only
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