AMBMP hydrochloride

Name: AMBMP hydrochloride
Brand: Tocris Bioscience
SKU: 6043

Tocris Bioscience a Bio-Techne Brand

Catalog # 6043

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Key Product Details

Description:	Wnt canonical signaling activator; also tubulin polymerization inhibitor
Alternative Names:	BML 284, CID 11210285
Chemical Name:	N⁴-(1,3-Benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	386.84

View Full Technical Details for AMBMP hydrochloride

Biological Activity for AMBMP hydrochloride

AMBMP hydrochloride is a Wnt canonical signaling activator. Also inhibits tubulin polymerization. Suppresses TLR2/4/5-induced inflammatory response in human monocytes. Inhibits cell proliferation and induces cell cycle arrest in MDA-MB-231 breast cancer cells. Also decreases embryo to blastocyst development.

Technical Data for AMBMP hydrochloride

M. Wt	386.84
Formula	C₁₉H₁₈N₄O₃.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2095432-75-8
PubChem ID	122705993
InChi Key	XZOFNDFDGVAIEH-UHFFFAOYSA-N
Smiles	COC1=CC=CC(C2=NC(N)=NC(NCC3=CC=C4OCOC4=C3)=C2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AMBMP hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	38.68	100

Preparing Stock Solutions for AMBMP hydrochloride

The following data is based on the product molecular weight 386.84.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.59 mL	12.93 mL	25.85 mL
5 mM	0.52 mL	2.59 mL	5.17 mL
10 mM	0.26 mL	1.29 mL	2.59 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for AMBMP hydrochloride

References are publications that support the biological activity of the product.

Wang 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine is an anti-inflammatory TLR-2, -4 and -5 response mediator in human monocytes. Inflamm.Res. 2016 PMID: 26613980
Fukuda Tubulin is a molecular target of the Wnt-activating chemical probe. BMC Biochem. 2016 PMID: 27207629
Denicol Canonical WNT signaling regulates development of bovine embryos to the blastocyst stage. Sci.Rep. 2013 PMID: 23405280
Liu A small-molecule agonist of the Wnt signaling pathway. Angew.Chem.Int.Ed.Engl. 2005 PMID: 15724259

Citations for AMBMP hydrochloride

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