Key Product Details
Description: | Selective CB2 inverse agonist |
Chemical Name: | 6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 504.37 |
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Citations for AM 630 (100)
Citations are publications that use Bio-Techne products. Selected citations for AM 630 include:
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Hohmann et al.
(2019)
On the influence of cannabinoids on cell morphology and motility of glioblastoma cells.
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Hohmann et al.
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Synthetic Cannabinoids Influence the Invasion of Glioblastoma Cell Lines in a Cell- and Receptor-Dependent Manner.
Cancers (Basel).
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Acevedo-Canabal et al.
(2019)
Altered Swimming Behaviors in Zebrafish Larvae Lacking Cannabinoid Receptor 2.
Cannabis Cannabinoid Res.
4:88
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Ghosh et al.
(2018)
The Endocannabinoid/Cannabinoid Receptor 2 System Protects Against Cisplatin-Induced Hearing Loss.
Front Cell Neurosci.
12:271
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Eubler et al.
(2018)
Ca2+ Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2.
Int J Mol Sci.
19
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Khan et al.
(2018)
Involvement of the CB2 cannabinoid receptor in cell growth inhibition and G0/G1 cell cycle arrest via the cannabinoid agonist WIN 55,212-2 in renal cell carcinoma.
BMC Cancer.
18:583
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Almada
(2017)
The synthetic cannabinoid WIN-55,212-55,212 induced-apoptosis in cytotrophoblasts cells by a mechanism dependent on CB1 receptor.
Toxicology.
385:67
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Kruk-Slomka et al.
(2016)
Correlations between the Memory-Related Behavior and the Level of Oxidative Stress Biomarkers in the Mice Brain, Provoked by an Acute Administration of CB Receptor Ligands.
Neural Plast.
2016:9815092
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Huang et al.
(2016)
Cannabinoid receptor subtype 2 (CB2R) agonist, GW405833 reduces agonist-induced Ca2+ oscillations in mouse pancreatic acinar cells
Scientific Reports.
6:29757
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Li and Kim
(2016)
CB2 Cannabinoid Receptor Knockout in Mice Impairs Contextual Long-Term Memory and Enhances Spatial Working Memory.
Mol Pharmacol.
2016:9817089
PMID: 26819779 -
Szczesniak et al.
(2016)
Cannabinoid 2 receptor is a novel anti-inflammatory target in experimental proliferative vitreoretinopathy
Neuropharmacology.
2016;
PMID: 27569993 -
Almada et al.
(2016)
The endocannabinoid anandamide impairs in vitro decidualization of human cells.
Reproduction.
152:351
PMID: 27568210 -
Krohn et al.
(2016)
Abnormal cannabidiol attenuates experimental colitis in mice, promotes wound healing and inhibits neutrophil recruitment.
J Inflamm (Lond).
13:21
PMID: 27418880 -
Blaha et al.
(2016)
Impaired Excitatory Neurotransmission in the Urinary Bladder from the Obese Zucker Rat: Role of Cannabinoid Receptors.
PLoS One.
11:e0157424
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Xie et al.
(2016)
Up-regulation of immunomodulatory effects of mouse bone-marrow derived mesenchymal stem cells by tetrahydrocannabinol pre-treatment involving cannabinoid receptor CB2.
Oncotarget.
7:6436
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Malek et al.
(2015)
Anandamide, Acting via CB2 Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures.
Neural Plast.
2015:130639
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Verty et al.
(2015)
Anti-Obesity Effect of the CB2 Receptor Agonist JWH-015 in Diet-Induced Obese Mice.
PLoS One.
10:e0140592
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Zhang et al.
(2015)
CB2R orchestrates fibrogenesis through regulation of inflammatory response during the repair of skeletal muscle contusion.
Mediators Inflamm.
8:3491
PMID: 26097533 -
Yang et al.
(2015)
Cannabinoid receptor CB2 is involved in tetrahydrocannabinol-induced anti-inflammation against lipopolysaccharide in MG-63 cells.
PLoS One.
2015:362126
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Woolcott et al.
(2015)
High-fat diet-induced Ins resistance does not increase plasma anandamide levels or potentiate anandamide Insotropic effect in isolated canine islets.
Br J Pharmacol.
10:e0123558
PMID: 25855974 -
Borrelli et al.
(2015)
Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent.
Sci Rep.
172:142
PMID: 25205418 -
Savonenko et al.
(2015)
Cannabinoid CB2 Receptors in a Mouse Model of Aβ Amyloidosis: Immunohistochemical Analysis and Suitability as a PET Biomarker of Neuroinflammation.
PLoS One.
10:e0129618
PMID: 26086915 -
Smith et al.
(2015)
The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation.
Neural Plast.
10:e0136546
PMID: 26414859 -
Stanley et al.
(2015)
Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB1 activation.
Sleep.
107:568
PMID: 26092099 -
Krishnan and Chatterjee
(2015)
Differential immune mechanism to HIV-1 Tat variants and its regulation by AEA [corrected].
PLoS One.
5:9887
PMID: 25943894 -
Sardinha et al.
(2014)
Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis.
Pain.
2014:978678
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Alpár et al.
(2014)
Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling.
Pharmacol Res.
5:4421
PMID: 25030704 -
Toguri et al.
(2014)
Anti-inflammatory effects of cannabinoid CB(2) receptor activation in endotoxin-induced uveitis.
PLoS One.
171:1448
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Wang et al.
(2014)
Treatment with a cannabinoid receptor 2 agonist decreases severity of established cystitis.
Br J Pharmacol.
191:1153
PMID: 24184363 -
Costa et al.
(2014)
2-arachidonoylglycerol effects in cytotrophoblasts: metabolic enzymes expression and apoptosis in BeWo cells.
Reproduction.
147:301
PMID: 24324206 -
Machado et al.
(2014)
Peripheral interactions between cannabinoid and opioid systems contribute to the antinociceptive effect of crotalphine.
Br J Pharmacol.
171:961
PMID: 24460677 -
Kury et al.
(2014)
Effects of the endogenous cannabinoid anandamide on voltage-dependent sodium and calcium channels in rat ventricular myocytes.
Br J Pharmacol.
171:3485
PMID: 24758718 -
Raver and Keller
(2014)
Permanent suppression of cortical oscillations in mice after adolescent exposure to cannabinoids: receptor mechanisms.
Neuropharmacology.
86:161
PMID: 25036610 -
Gonzalez et al.
(2013)
Deriving DArgic neurons for clinical use. A practical approach.
Sci Rep.
3:1463
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Sreevalsan and Safe
(2013)
The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells.
Mol Cancer Ther.
12:2483
PMID: 24030632 -
Marini et al.
(2013)
Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors.
Br J Pharmacol.
169:887
PMID: 23711022 -
Tchantchou and Zhang
(2013)
Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury.
J Neurotrauma.
30:565
PMID: 23151067 -
Costola-de-Souza et al.
(2013)
Monoacylglycerol lipase (MAGL) inhibition attenuates acute lung injury in mice.
PLoS One.
8:e77706
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Wang et al.
(2013)
Activation of cannabinoid receptor 2 inhibits experimental cystitis.
Br J Pharmacol.
304:R846
PMID: 23515618 -
Li et al.
(2013)
Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells.
Br J Pharmacol.
170:489
PMID: 23347118 -
Uhelski et al.
(2013)
The non-selective cannabinoid receptor agonist WIN 55,212-2 attenuates responses of C-fiber nociceptors in a murine model of cancer pain.
Neuroscience.
247:84
PMID: 23673278 -
Rossi et al.
(2013)
The cannabinoid receptor type 2 as mediator of mesenchymal stromal cell immunosuppressive properties.
PLoS One.
8:e80022
PMID: 24312195 -
Murineddu et al.
(2012)
Tricyclic Pyrazoles. Part 5. Novel 1,4-Dihydroindeno[1,2-c]pyrazole CB2 Ligands Using Molecular Hybridization Based on Scaffold Hopping.
Open Med Chem J.
6:1
PMID: 22876271 -
Guida et al.
(2012)
Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection.
Mol Pain.
8:60
PMID: 22913292 -
Tumati et al.
(2012)
Repeated mor. treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist.
J Neuroimmunol.
244:23
PMID: 22285397 -
Liu et al.
(2012)
Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer.
Mol Cancer Ther.
11:1421
PMID: 22553354 -
Bolognini et al.
(2012)
AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor.
Br J Pharmacol.
165:2561
PMID: 21615724 -
García-Gutiérrez et al.
(2012)
Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABA(A) receptors.
Br J Pharmacol.
165:951
PMID: 21838753 -
Niu et al.
(2012)
Effects of gonadal hormones on the peripheral cannabinoid receptor 1 (CB1R) system under a myositis condition in rats.
Br J Pharmacol.
153:2283
PMID: 22940464 -
Arévalo-Martín et al.
(2012)
Early endogenous activation of CB1 and CB2 receptors after spinal cord injury is a protective response involved in spontaneous recovery.
Mol Pharmacol.
7:e49057
PMID: 23152849 -
Piro et al.
(2012)
A dysregulated endocannabinoid-eicosanoid network supports pathogenesis in a mouse model of Alzheimer's disease.
Eur J Pharmacol.
1:617
PMID: 22813736 -
Merighi et al.
(2012)
Cannabinoid CB(2) receptors modulate ERK-1/2 kinase signalling and NO release in microglial cells stimulated with bacterial lipopolysaccharide.
Br J Pharmacol.
165:1773
PMID: 21951063 -
Navarrete et al.
(2012)
Cannabinoid CB? receptor-mediated regulation of impulsive-like behaviour in DBA/2 mice.
Br J Pharmacol.
165:260
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Tauber et al.
(2012)
Regulation of MMP-9 by a WIN-binding site in the monocyte-macrophage system independent from cannabinoid receptors.
PLoS One.
7:e48272
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Bashashati et al.
(2012)
Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice.
Br J Pharmacol.
165:1556
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Merighi et al.
(2012)
Cannabinoid CB(2) receptor attenuates morphine-induced inflammatory responses in activated microglial cells.
Br J Pharmacol.
166:2371
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Landry et al.
(2012)
Spinal cannabinoid receptor type 2 agonist reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatases in a rat model of neuropathic pain.
J Pain.
13:836
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Bento et al.
(2011)
β-Caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPARγ pathway.
Am J Pathol.
178:1153
PMID: 21356367 -
Barutta et al.
(2011)
Protective role of cannabinoid receptor type 2 in a mouse model of diabetic nephropathy.
Diabetes.
60:2386
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Lombard et al.
(2011)
Perinatal exposure to δ9-tetrahydrocannabinol triggers profound defects in T cell differentiation and function in fetal and postnatal stages of life, including decreased responsiveness to HIV antigens.
J Pharmacol Exp Ther.
339:607
PMID: 21831965 -
Khasabova et al.
(2011)
Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain.
FASEB J.
64:60
PMID: 21440630 -
Negrete et al.
(2011)
The antinociceptive effects of JWH-015 in chronic inflammatory pain are produced by nitric oxide-cGMP-PKG-KATP pathway activation mediated by opioids.
PLoS One.
6:e26688
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Brown et al.
(2010)
Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines.
Carcinogenesis.
31:1584
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Alkaitis et al.
(2010)
Evidence for a role of endocannabinoids, astrocytes and p38 phosphorylation in the resolution of postoperative pain.
PLoS One.
5:e10891
PMID: 20531936 -
Dmitrieva et al.
(2010)
Endocannabinoid involvement in endometriosis.
Pain.
151:703
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Mair et al.
(2010)
Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery.
Br J Pharmacol.
161:176
PMID: 20718749 -
Buznikov et al.
(2010)
A putative 'pre-nervous' endocannabinoid system in early echinoderm development.
Neurobiol Dis.
32:43101
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Hao et al.
(2010)
The cannabinoid WIN55,212-2 protects against oxidized LDL-induced inflammatory response in murine macrophages.
J Leukoc Biol.
51:2181
PMID: 20305287 -
Hervera et al.
(2010)
The role of nitric oxide in the local antiallodynic and antihyperalgesic effects and expression of delta-opioid and cannabinoid-2 receptors during neuropathic pain in mice.
J Pharmacol Exp Ther.
334:887
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Schuelert et al.
(2010)
Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain.
Osteoarthritis Cartilage.
18:1536
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Touriño et al.
(2010)
THC Prevents MDMA Neurotoxicity in Mice.
PLoS One.
5:e9143
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Han et al.
(2009)
CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages.
Cardiovasc Res.
84:378
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Fraga et al.
(2009)
Endogenous cannabinoids induce fever through the activation of CB1 receptors.
Mediators Inflamm.
157:1494
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Meuth et al.
(2009)
The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice.
Am J Physiol Heart Circ Physiol.
33:42675
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Defer et al.
(2009)
The cannabinoid receptor type 2 promotes cardiac myocyte and fibroblast survival and protects against ischemia/reperfusion-induced cardiomyopathy.
PLoS One.
23:2120
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Deveaux et al.
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Cannabinoid CB2 receptor potentiates obesity-associated inflammation, Ins resistance and hepatic steatosis.
Am J Physiol Regul Integr Comp Physiol.
4:e5844
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Pacheco et al.
(2009)
Central antinociception induced by mu-opioid receptor agonist morphine, but not delta- or kappa-, is mediated by cannabinoid CB1 receptor.
Br J Pharmacol.
158:225
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Rajesh et al.
(2008)
CB2 cannabinoid receptor agonists attenuate TNF-alpha-induced human vascular smooth muscle cell proliferation and migration.
Br J Pharmacol.
153:347
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Potenzieri et al.
(2008)
The cannabinoid receptor agonist, WIN 55, 212-2, attenuates tumor-evoked hyperalgesia through peripheral mechanisms.
Brain Res.
1215:69
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Börner et al.
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Analysis of promoter regions regulating basal and interleukin-4-inducible expression of the human CB1 receptor gene in T lymphocytes.
Br J Pharmacol.
73:1013
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Desroches et al.
(2008)
Modulation of the anti-nociceptive effects of 2-arachidonoyl glycerol by peripherally administered FAAH and MGL inhibitors in a neuropathic pain model.
J Lipid Res.
155:913
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Pacheco et al.
(2008)
The mu-opioid receptor agonist morphine, but not agonists at delta- or kappa-opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors.
Br J Pharmacol.
154:1143
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Mukhopadhyay et al.
(2007)
Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity.
J Am Coll Cardiol.
50:528
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Rajesh et al.
(2007)
Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption.
Am J Physiol Heart Circ Physiol.
293:H610
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Rajesh et al.
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CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion.
Am J Physiol Heart Circ Physiol.
293:H2210
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Bátkai et al.
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Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase.
Int J Clin Exp Pathol.
293:H909
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Saitoh et al.
(2007)
The differential contractile responses to capsaicin and anandamide in muscle strips isolated from the rat urinary bladder.
J Cell Biol.
570:182
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Ghasemi et al.
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Role of the nitric oxide pathway and the endocannabinoid system in neurogenic relaxation of corpus cavernosum from biliary cirrhotic rats.
Br J Pharmacol.
151:591
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Rajesh et al.
(2007)
Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis.
Cardiovasc Res.
82:1382
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Hama
(2007)
Antinociceptive effect of cannabinoid agonist WIN 55,212-2 in rats with a spinal cord injury.
Exp Neurol.
204:454
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Akerman et al.
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Cannabinoid (CB1) receptor activation inhibits trigeminovascular neurons.
J Pharmacol Exp Ther.
320:64
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Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB(1) and VR(1) receptors.
Dev Neurosci.
149:898
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Börner et al.
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Cannabinoid receptor type 2 agonists induce transcription of the mu-opioid receptor gene in Jurkat T cells.
Cell Rep.
69:1486
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Role of endocannabinoids in the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats.
Nat Commun.
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Mathison et al.
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Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats.
Br J Pharmacol.
142:1247
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Price et al.
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Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons.
Br J Pharmacol.
142:257
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Baker
(2004)
The cannabinomimetic arachidonyl-2-chloroethylamide (ACEA) acts on capsaicin-sensitive TRPV1 receptors but not cannabinoid receptors in rat joints.
Br J Pharmacol.
142:1361
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Williams et al.
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The FGF receptor uses the endocannabinoid signaling system to couple to an axonal growth response.
J Urol.
160:481
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Ford et al.
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Evidence of a novel site mediating anandamide-induced negative inotropic and coronary vasodilatator responses in rat isolated hearts.
Br J Pharmacol.
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Jiang et al.
Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells.
PLoS One.
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