AM 630

Citations are publications that use Bio-Techne products. Selected citations for AM 630 include:

• Hohmann et al. (2019) On the influence of cannabinoids on cell morphology and motility of glioblastoma cells. PLoS One. 14:e0212037
  PMID: 30753211
• Hohmann et al. (2019) Synthetic Cannabinoids Influence the Invasion of Glioblastoma Cell Lines in a Cell- and Receptor-Dependent Manner. Cancers (Basel). 11
  PMID: 30709059
• Acevedo-Canabal et al. (2019) Altered Swimming Behaviors in Zebrafish Larvae Lacking Cannabinoid Receptor 2. Cannabis Cannabinoid Res. 4:88
  PMID: 31236475
• Ghosh et al. (2018) The Endocannabinoid/Cannabinoid Receptor 2 System Protects Against Cisplatin-Induced Hearing Loss. Front Cell Neurosci. 12:271
  PMID: 30186120
• Eubler et al. (2018) Ca2+ Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 19
  PMID: 30235802
• Khan et al. (2018) Involvement of the CB₂ cannabinoid receptor in cell growth inhibition and G0/G1 cell cycle arrest via the cannabinoid agonist WIN 55,212-2 in renal cell carcinoma. BMC Cancer. 18:583
  PMID: 29792186
• Almada (2017) The synthetic cannabinoid WIN-55,212-55,212 induced-apoptosis in cytotrophoblasts cells by a mechanism dependent on CB1 receptor. Toxicology. 385:67
  PMID: 28495606
• Kruk-Slomka et al. (2016) Correlations between the Memory-Related Behavior and the Level of Oxidative Stress Biomarkers in the Mice Brain, Provoked by an Acute Administration of CB Receptor Ligands. Neural Plast. 2016:9815092
  PMID: 26839719
• Huang et al. (2016) Cannabinoid receptor subtype 2 (CB2R) agonist, GW405833 reduces agonist-induced Ca2+ oscillations in mouse pancreatic acinar cells Scientific Reports. 6:29757
  PMID: 27432473
• Li and Kim (2016) CB2 Cannabinoid Receptor Knockout in Mice Impairs Contextual Long-Term Memory and Enhances Spatial Working Memory. Mol Pharmacol. 2016:9817089
  PMID: 26819779
• Szczesniak et al. (2016) Cannabinoid 2 receptor is a novel anti-inflammatory target in experimental proliferative vitreoretinopathy Neuropharmacology. 2016;
  PMID: 27569993
• Almada et al. (2016) The endocannabinoid anandamide impairs in vitro decidualization of human cells. Reproduction. 152:351
  PMID: 27568210
• Krohn et al. (2016) Abnormal cannabidiol attenuates experimental colitis in mice, promotes wound healing and inhibits neutrophil recruitment. J Inflamm (Lond). 13:21
  PMID: 27418880
• Blaha et al. (2016) Impaired Excitatory Neurotransmission in the Urinary Bladder from the Obese Zucker Rat: Role of Cannabinoid Receptors. PLoS One. 11:e0157424
  PMID: 27285468
• Xie et al. (2016) Up-regulation of immunomodulatory effects of mouse bone-marrow derived mesenchymal stem cells by tetrahydrocannabinol pre-treatment involving cannabinoid receptor CB2. Oncotarget. 7:6436
  PMID: 26824325
• Malek et al. (2015) Anandamide, Acting via CB2 Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures. Neural Plast. 2015:130639
  PMID: 26090232
• Verty et al. (2015) Anti-Obesity Effect of the CB2 Receptor Agonist JWH-015 in Diet-Induced Obese Mice. PLoS One. 10:e0140592
  PMID: 26588700
• Zhang et al. (2015) CB2R orchestrates fibrogenesis through regulation of inflammatory response during the repair of skeletal muscle contusion. Mediators Inflamm. 8:3491
  PMID: 26097533
• Yang et al. (2015) Cannabinoid receptor CB2 is involved in tetrahydrocannabinol-induced anti-inflammation against lipopolysaccharide in MG-63 cells. PLoS One. 2015:362126
  PMID: 25653478
• Woolcott et al. (2015) High-fat diet-induced Ins resistance does not increase plasma anandamide levels or potentiate anandamide Insotropic effect in isolated canine islets. Br J Pharmacol. 10:e0123558
  PMID: 25855974
• Borrelli et al. (2015) Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent. Sci Rep. 172:142
  PMID: 25205418
• Savonenko et al. (2015) Cannabinoid CB2 Receptors in a Mouse Model of Aβ Amyloidosis: Immunohistochemical Analysis and Suitability as a PET Biomarker of Neuroinflammation. PLoS One. 10:e0129618
  PMID: 26086915
• Smith et al. (2015) The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation. Neural Plast. 10:e0136546
  PMID: 26414859
• Stanley et al. (2015) Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB1 activation. Sleep. 107:568
  PMID: 26092099
• Krishnan and Chatterjee (2015) Differential immune mechanism to HIV-1 Tat variants and its regulation by AEA [corrected]. PLoS One. 5:9887
  PMID: 25943894
• Sardinha et al. (2014) Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis. Pain. 2014:978678
  PMID: 24803745
• Alpár et al. (2014) Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling. Pharmacol Res. 5:4421
  PMID: 25030704
• Toguri et al. (2014) Anti-inflammatory effects of cannabinoid CB(2) receptor activation in endotoxin-induced uveitis. PLoS One. 171:1448
  PMID: 24308861
• Wang et al. (2014) Treatment with a cannabinoid receptor 2 agonist decreases severity of established cystitis. Br J Pharmacol. 191:1153
  PMID: 24184363
• Costa et al. (2014) 2-arachidonoylglycerol effects in cytotrophoblasts: metabolic enzymes expression and apoptosis in BeWo cells. Reproduction. 147:301
  PMID: 24324206
• Machado et al. (2014) Peripheral interactions between cannabinoid and opioid systems contribute to the antinociceptive effect of crotalphine. Br J Pharmacol. 171:961
  PMID: 24460677
• Kury et al. (2014) Effects of the endogenous cannabinoid anandamide on voltage-dependent sodium and calcium channels in rat ventricular myocytes. Br J Pharmacol. 171:3485
  PMID: 24758718
• Raver and Keller (2014) Permanent suppression of cortical oscillations in mice after adolescent exposure to cannabinoids: receptor mechanisms. Neuropharmacology. 86:161
  PMID: 25036610
• Gonzalez et al. (2013) Deriving DArgic neurons for clinical use. A practical approach. Sci Rep. 3:1463
  PMID: 23492920
• Sreevalsan and Safe (2013) The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells. Mol Cancer Ther. 12:2483
  PMID: 24030632
• Marini et al. (2013) Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors. Br J Pharmacol. 169:887
  PMID: 23711022
• Tchantchou and Zhang (2013) Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury. J Neurotrauma. 30:565
  PMID: 23151067
• Costola-de-Souza et al. (2013) Monoacylglycerol lipase (MAGL) inhibition attenuates acute lung injury in mice. PLoS One. 8:e77706
  PMID: 24204926
• Wang et al. (2013) Activation of cannabinoid receptor 2 inhibits experimental cystitis. Br J Pharmacol. 304:R846
  PMID: 23515618
• Li et al. (2013) Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells. Br J Pharmacol. 170:489
  PMID: 23347118
• Uhelski et al. (2013) The non-selective cannabinoid receptor agonist WIN 55,212-2 attenuates responses of C-fiber nociceptors in a murine model of cancer pain. Neuroscience. 247:84
  PMID: 23673278
• Rossi et al. (2013) The cannabinoid receptor type 2 as mediator of mesenchymal stromal cell immunosuppressive properties. PLoS One. 8:e80022
  PMID: 24312195
• Murineddu et al. (2012) Tricyclic Pyrazoles. Part 5. Novel 1,4-Dihydroindeno[1,2-c]pyrazole CB2 Ligands Using Molecular Hybridization Based on Scaffold Hopping. Open Med Chem J. 6:1
  PMID: 22876271
• Guida et al. (2012) Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection. Mol Pain. 8:60
  PMID: 22913292
• Tumati et al. (2012) Repeated mor. treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist. J Neuroimmunol. 244:23
  PMID: 22285397
• Liu et al. (2012) Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer. Mol Cancer Ther. 11:1421
  PMID: 22553354
• Bolognini et al. (2012) AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor. Br J Pharmacol. 165:2561
  PMID: 21615724
• García-Gutiérrez et al. (2012) Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABA(A) receptors. Br J Pharmacol. 165:951
  PMID: 21838753
• Niu et al. (2012) Effects of gonadal hormones on the peripheral cannabinoid receptor 1 (CB1R) system under a myositis condition in rats. Br J Pharmacol. 153:2283
  PMID: 22940464
• Arévalo-Martín et al. (2012) Early endogenous activation of CB1 and CB2 receptors after spinal cord injury is a protective response involved in spontaneous recovery. Mol Pharmacol. 7:e49057
  PMID: 23152849
• Piro et al. (2012) A dysregulated endocannabinoid-eicosanoid network supports pathogenesis in a mouse model of Alzheimer's disease. Eur J Pharmacol. 1:617
  PMID: 22813736
• Merighi et al. (2012) Cannabinoid CB(2) receptors modulate ERK-1/2 kinase signalling and NO release in microglial cells stimulated with bacterial lipopolysaccharide. Br J Pharmacol. 165:1773
  PMID: 21951063
• Navarrete et al. (2012) Cannabinoid CB? receptor-mediated regulation of impulsive-like behaviour in DBA/2 mice. Br J Pharmacol. 165:260
  PMID: 21671903
• Tauber et al. (2012) Regulation of MMP-9 by a WIN-binding site in the monocyte-macrophage system independent from cannabinoid receptors. PLoS One. 7:e48272
  PMID: 23139770
• Bashashati et al. (2012) Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice. Br J Pharmacol. 165:1556
  PMID: 21883147
• Merighi et al. (2012) Cannabinoid CB(2) receptor attenuates morphine-induced inflammatory responses in activated microglial cells. Br J Pharmacol. 166:2371
  PMID: 22428664
• Landry et al. (2012) Spinal cannabinoid receptor type 2 agonist reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatases in a rat model of neuropathic pain. J Pain. 13:836
  PMID: 22901764
• Bento et al. (2011) β-Caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPARγ pathway. Am J Pathol. 178:1153
  PMID: 21356367
• Barutta et al. (2011) Protective role of cannabinoid receptor type 2 in a mouse model of diabetic nephropathy. Diabetes. 60:2386
  PMID: 21810593
• Lombard et al. (2011) Perinatal exposure to δ9-tetrahydrocannabinol triggers profound defects in T cell differentiation and function in fetal and postnatal stages of life, including decreased responsiveness to HIV antigens. J Pharmacol Exp Ther. 339:607
  PMID: 21831965
• Khasabova et al. (2011) Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain. FASEB J. 64:60
  PMID: 21440630
• Negrete et al. (2011) The antinociceptive effects of JWH-015 in chronic inflammatory pain are produced by nitric oxide-cGMP-PKG-KATP pathway activation mediated by opioids. PLoS One. 6:e26688
  PMID: 22031841
• Brown et al. (2010) Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines. Carcinogenesis. 31:1584
  PMID: 20660502
• Alkaitis et al. (2010) Evidence for a role of endocannabinoids, astrocytes and p38 phosphorylation in the resolution of postoperative pain. PLoS One. 5:e10891
  PMID: 20531936
• Dmitrieva et al. (2010) Endocannabinoid involvement in endometriosis. Pain. 151:703
  PMID: 20833475
• Mair et al. (2010) Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery. Br J Pharmacol. 161:176
  PMID: 20718749
• Buznikov et al. (2010) A putative 'pre-nervous' endocannabinoid system in early echinoderm development. Neurobiol Dis. 32:43101
  PMID: 19907129
• Hao et al. (2010) The cannabinoid WIN55,212-2 protects against oxidized LDL-induced inflammatory response in murine macrophages. J Leukoc Biol. 51:2181
  PMID: 20305287
• Hervera et al. (2010) The role of nitric oxide in the local antiallodynic and antihyperalgesic effects and expression of delta-opioid and cannabinoid-2 receptors during neuropathic pain in mice. J Pharmacol Exp Ther. 334:887
  PMID: 20498253
• Schuelert et al. (2010) Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain. Osteoarthritis Cartilage. 18:1536
  PMID: 20863899
• Touriño et al. (2010) THC Prevents MDMA Neurotoxicity in Mice. PLoS One. 5:e9143
  PMID: 20174577
• Han et al. (2009) CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages. Cardiovasc Res. 84:378
  PMID: 19596672
• Fraga et al. (2009) Endogenous cannabinoids induce fever through the activation of CB1 receptors. Mediators Inflamm. 157:1494
  PMID: 19681872
• Meuth et al. (2009) The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice. Am J Physiol Heart Circ Physiol. 33:42675
  PMID: 18930826
• Defer et al. (2009) The cannabinoid receptor type 2 promotes cardiac myocyte and fibroblast survival and protects against ischemia/reperfusion-induced cardiomyopathy. PLoS One. 23:2120
  PMID: 19246487
• Deveaux et al. (2009) Cannabinoid CB2 receptor potentiates obesity-associated inflammation, Ins resistance and hepatic steatosis. Am J Physiol Regul Integr Comp Physiol. 4:e5844
  PMID: 19513120
• Pacheco et al. (2009) Central antinociception induced by mu-opioid receptor agonist morphine, but not delta- or kappa-, is mediated by cannabinoid CB1 receptor. Br J Pharmacol. 158:225
  PMID: 19594755
• Rajesh et al. (2008) CB2 cannabinoid receptor agonists attenuate TNF-alpha-induced human vascular smooth muscle cell proliferation and migration. Br J Pharmacol. 153:347
  PMID: 17994109
• Potenzieri et al. (2008) The cannabinoid receptor agonist, WIN 55, 212-2, attenuates tumor-evoked hyperalgesia through peripheral mechanisms. Brain Res. 1215:69
  PMID: 18486111
• Börner et al. (2008) Analysis of promoter regions regulating basal and interleukin-4-inducible expression of the human CB1 receptor gene in T lymphocytes. Br J Pharmacol. 73:1013
  PMID: 18156315
• Desroches et al. (2008) Modulation of the anti-nociceptive effects of 2-arachidonoyl glycerol by peripherally administered FAAH and MGL inhibitors in a neuropathic pain model. J Lipid Res. 155:913
  PMID: 18695638
• Pacheco et al. (2008) The mu-opioid receptor agonist morphine, but not agonists at delta- or kappa-opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors. Br J Pharmacol. 154:1143
  PMID: 18469844
• Mukhopadhyay et al. (2007) Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity. J Am Coll Cardiol. 50:528
  PMID: 17678736
• Rajesh et al. (2007) Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption. Am J Physiol Heart Circ Physiol. 293:H610
  PMID: 17384130
• Rajesh et al. (2007) CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion. Am J Physiol Heart Circ Physiol. 293:H2210
  PMID: 17660390
• Bátkai et al. (2007) Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase. Int J Clin Exp Pathol. 293:H909
  PMID: 17434980
• Saitoh et al. (2007) The differential contractile responses to capsaicin and anandamide in muscle strips isolated from the rat urinary bladder. J Cell Biol. 570:182
  PMID: 17586490
• Ghasemi et al. (2007) Role of the nitric oxide pathway and the endocannabinoid system in neurogenic relaxation of corpus cavernosum from biliary cirrhotic rats. Br J Pharmacol. 151:591
  PMID: 17486141
• Rajesh et al. (2007) Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis. Cardiovasc Res. 82:1382
  PMID: 17652447
• Hama (2007) Antinociceptive effect of cannabinoid agonist WIN 55,212-2 in rats with a spinal cord injury. Exp Neurol. 204:454
  PMID: 17045264
• Akerman et al. (2007) Cannabinoid (CB1) receptor activation inhibits trigeminovascular neurons. J Pharmacol Exp Ther. 320:64
  PMID: 17018694
• Moezi et al. (2006) Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB(1) and VR(1) receptors. Dev Neurosci. 149:898
  PMID: 17043671
• Börner et al. (2006) Cannabinoid receptor type 2 agonists induce transcription of the mu-opioid receptor gene in Jurkat T cells. Cell Rep. 69:1486
  PMID: 16434616
• Gaskari et al. (2005) Role of endocannabinoids in the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats. Nat Commun. 146:315
  PMID: 16025138
• Mathison et al. (2004) Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats. Br J Pharmacol. 142:1247
  PMID: 15249429
• Price et al. (2004) Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons. Br J Pharmacol. 142:257
  PMID: 15155534
• Baker (2004) The cannabinomimetic arachidonyl-2-chloroethylamide (ACEA) acts on capsaicin-sensitive TRPV1 receptors but not cannabinoid receptors in rat joints. Br J Pharmacol. 142:1361
  PMID: 15277316
• Williams et al. (2003) The FGF receptor uses the endocannabinoid signaling system to couple to an axonal growth response. J Urol. 160:481
  PMID: 12578907
• Ford et al. (2002) Evidence of a novel site mediating anandamide-induced negative inotropic and coronary vasodilatator responses in rat isolated hearts. Br J Pharmacol. 135:1191
  PMID: 11877326
• Jiang et al. Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells. PLoS One. 2:e641
  PMID: 17653268

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