ALX 5407 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1757
Selective non-transportable GlyT1 inhibitor
Key Product Details
Description
Selective non-transportable GlyT1 inhibitor
Alternative Names
(+)-NFPS
Product Description
ALX 5407 hydrochloride is a selective non-transportable inhibitor of the glycine transporter GlyT1 (IC50 values are 3 nM and > 100 μM for human GlyT1c and GlyT2 respectively). Does not recognize other glycine sites, including the glycine site on the NMDA receptor (IC50 > 100 μM).Racemate also available.
Licensing Information
Sold with the permission of NPS Pharmaceuticals Inc. Strictly for in vitro use onlyProduct Specifications
Molecular Weight
429.92
Formula
C24H24FNO3.HCl
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine hydrochloride
CAS Number
200006-08-2
PubChem ID
16078946
InChI Key
RPDGSZCYSJWQEE-GNAFDRTKSA-N
SMILES
FC(C=C2)=CC=C2[C@@H](CCN(CC(O)=O)C)OC1=CC=C(C3=CC=CC=C3)C=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.99 | 100 | |
| Ethanol | 21.5 | 50 |
Preparing Stock Solutions
for ALX 5407 hydrochloride
The following data is based on the product molecular weight 429.92
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.33 mL | 11.63 mL | 23.26 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.65 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.33 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lipina Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to cloz. in mouse models of schizophrenia. Psychopharmacology 2005 PMID: 15759151
- Atkinson ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. Mol.Pharmacol. 2001 PMID: 11723250
Product Specific Notices for ALX 5407 hydrochloride
For research use only
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