ALX 5407 hydrochloride

Name: ALX 5407 hydrochloride
Brand: Tocris Bioscience
SKU: 1757

Tocris Bioscience, part of Bio-Techne | Catalog # 1757

Citations (10)

COA / SDS

Selective non-transportable GlyT1 inhibitor

Key Product Details

Description:	Selective non-transportable GlyT1 inhibitor
Alternative Names:	(+)-NFPS
Chemical Name:	N-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	429.92

View Full Technical Details for ALX 5407 hydrochloride

Technical Data
Citations

Biological Activity for ALX 5407 hydrochloride

ALX 5407 hydrochloride is a selective non-transportable inhibitor of the glycine transporter GlyT1 (IC₅₀ values are 3 nM and > 100 μM for human GlyT1c and GlyT2 respectively). Does not recognize other glycine sites, including the glycine site on the NMDA receptor (IC₅₀ > 100 μM).

Racemate also available.

Licensing Information

Sold with the permission of NPS Pharmaceuticals Inc. Strictly for in vitro use only

Compound Libraries for ALX 5407 hydrochloride

ALX 5407 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ALX 5407 hydrochloride

M. Wt	429.92
Formula	C₂₄H₂₄FNO₃.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	200006-08-2
PubChem ID	16078946
InChi Key	RPDGSZCYSJWQEE-GNAFDRTKSA-N
Smiles	FC(C=C2)=CC=C2[C@@H](CCN(CC(O)=O)C)OC1=CC=C(C3=CC=CC=C3)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ALX 5407 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	21.5	50
	DMSO	42.99	100

Preparing Stock Solutions for ALX 5407 hydrochloride

The following data is based on the product molecular weight 429.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.63 mL	23.26 mL
5 mM	0.47 mL	2.33 mL	4.65 mL
10 mM	0.23 mL	1.16 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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References for ALX 5407 hydrochloride

References are publications that support the biological activity of the product.

Lipina Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to cloz. in mouse models of schizophrenia. Psychopharmacology 2005 PMID: 15759151
Atkinson ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. Mol.Pharmacol. 2001 PMID: 11723250