Alprenolol hydrochloride

Name: Alprenolol hydrochloride
Brand: Tocris Bioscience
SKU: 2806
Rating: 3 (1 reviews)

Catalog # 2806 | Tocris Bioscience a Bio-Techne Brand

(1)

COA / SDS

β antagonist; also 5-HT1A antagonist

Key Product Details

Description:	β antagonist; also 5-HT_1A antagonist
Chemical Name:	1-[(1-Methylethyl)amino]-3-[2-(2-propenyl)phenoxy]-2-propanol hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	285.81

View Full Technical Details for Alprenolol hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Alprenolol hydrochloride

Alprenolol hydrochloride is a β-adrenoceptor (β₂ > β₁ > β₃) and 5-HT_1A receptor antagonist.

Technical Data for Alprenolol hydrochloride

M. Wt	285.81
Formula	C₁₅H₂₃NO₂.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	13707-88-5
PubChem ID	66368
InChi Key	RRCPAXJDDNWJBI-UHFFFAOYSA-N
Smiles	C=CCC1=CC=CC=C1OCC(O)CNC(C)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Alprenolol hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	28.58	100

Preparing Stock Solutions for Alprenolol hydrochloride

The following data is based on the product molecular weight 285.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.50 mL	17.49 mL	34.99 mL
5 mM	0.70 mL	3.50 mL	7.00 mL
10 mM	0.35 mL	1.75 mL	3.50 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

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Reconstitution Calculator

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References for Alprenolol hydrochloride

References are publications that support the biological activity of the product.

Baker The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br.J.Pharmacol. 2005 PMID: 15655528
Bjorvatin The 5-HT_1A antagonist (-)-alprenolol fails to modify sleep or zimeldine-induced sleep-waking effects in rats. Pharmacol.Biochem.Behav. 1992 PMID: 1388278
Blue Antagonist characterization of atypical beta adrenoceptors in guinea pig ileum: blockade by alprenolol and dihydroalprenolol. J.Pharmacol.Exp.Ther. 1990 PMID: 1969469

Citations for Alprenolol hydrochloride

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Customer Reviews for Alprenolol hydrochloride (1)

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Beta2 adrenergic blocker

Name: Anonymous

Species: Mouse

Assay Type: Ex Vivo

Cell Line/Tissue: Acute brain slices

Beta-2 receptor blocker used in brain slices. No effect was found, although not sure if it was due to lack of blockade or lack of involvement of B2R in the observed process

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