α-MSH

Name: α-MSH
Brand: Tocris Bioscience
SKU: 2584

Tocris Bioscience, part of Bio-Techne | Catalog # 2584

Citations (9)

COA / SDS

Endogenous melanocortin receptor agonist

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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Endogenous melanocortin receptor agonist

Alternative Names

α-Melanotropin,α-Melanocyte-stimulating hormone

View all Melanocortin Receptor Agonists »

Product Description

α-MSH is an endogenous melanocortin receptor agonist (K_i values are 0.12, 31, 660 and 5700 nM for MC₁, MC₃, MC₄ and MC₅ receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-inflammatory cytokine IL-10. Inhibits food intake and induces penile erections following i.c.v. administration.

Product Specifications

Molecular Weight

1664.90

Formula

C₇₇H₁₀₉N₂₁O₁₉S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

581-05-5

PubChem ID

16132144

InChI Key

WHNFPRLDDSXQCL-UAZQEYIDSA-N

SMILES

CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 0.6mg/ml in water

Calculators

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product.

Mizusawa Alpha-melanocyte stimulating hormone and oxyt. induced penile erections, and intracavernous pressure increases in the rat. J.Urol. 2002 PMID: 11792967
Yamaoka-Tojo Central neurotranspeptide, alpha-melanocyte-stimulating hormone (α-MSH) is upregulated in patients with congestive heart failure. Intern.Med. 2006 PMID: 16679696
Wikber Melanocortin receptors: perspectives for novel drugs. Eur.J.Pharmacol. 1999 PMID: 10443584