Allopregnanolone

Name: Allopregnanolone
Brand: Tocris Bioscience
SKU: 3653

Tocris Bioscience a Bio-Techne Brand

Catalog # 3653

Citations (2)

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Key Product Details

Description:	Positive allosteric modulator of GABA_A receptors
Alternative Names:	3a,5a-THPROG
Chemical Name:	(3α,5α)-3-Hydroxy-pregnan-20-one
Molecular Weight:	318.49

View Full Technical Details for Allopregnanolone

Biological Activity for Allopregnanolone

Allopregnanolone is a GABA_A receptor positive allosteric modulator. Neuroactive steroid.

Technical Data for Allopregnanolone

M. Wt	318.49
Formula	C₂₁H₃₄O₂
Storage	Store at RT
CAS Number	516-54-1
PubChem ID	92786
InChi Key	AURFZBICLPNKBZ-SYBPFIFISA-N
Smiles	C[C@@]12[C@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(C)=O)([H])C[C@H](O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Allopregnanolone

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	31.85	100
	ethanol	31.85	100

Preparing Stock Solutions for Allopregnanolone

The following data is based on the product molecular weight 318.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.14 mL	15.70 mL	31.40 mL
5 mM	0.63 mL	3.14 mL	6.28 mL
10 mM	0.31 mL	1.57 mL	3.14 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

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References for Allopregnanolone

References are publications that support the biological activity of the product.

Agis-Balboa Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc.Natl.Acad.Sci.USA
Belelli and Lambert Neurosteroids: endogenous regulators of the GABA_A receptor. Nat.Rev.Neurosci. 2005 PMID: 15959466
Puia Neurosteroids act on recombinant human GABA_A receptors. Neuron 1990 PMID: 2160838

Citations for Allopregnanolone (2)

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Citations are publications that use Bio-Techne products. Selected citations for Allopregnanolone include:

Ferando and Mody (2013) Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons. Front Neural Circuits. 7:144
PMID: 24062647
Earl (2011) Inhibition of recombinant L-type voltage-gated calcium channels by positive allosteric modulators of GABAA receptors. J Pharmacol Exp Ther. 337:301
PMID: 21262851

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Product Documents for Allopregnanolone

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.