Allopregnanolone
Tocris Bioscience, part of Bio-Techne | Catalog # 3653
Positive allosteric modulator of GABAA receptors
Key Product Details
Description
Positive allosteric modulator of GABAA receptors
Alternative Names
3a,5a-THPROG
Product Description
Allopregnanolone is a GABAA receptor positive allosteric modulator. Neuroactive steroid.Product Specifications
Molecular Weight
318.49
Formula
C21H34O2
Storage
Store at RT
Chemical Name
(3α,5α)-3-Hydroxy-pregnan-20-one
CAS Number
516-54-1
PubChem ID
92786
InChI Key
AURFZBICLPNKBZ-SYBPFIFISA-N
SMILES
C[C@@]12[C@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(C)=O)([H])C[C@H](O)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.85 | 100 | |
| Ethanol | 31.85 | 100 |
Preparing Stock Solutions
for Allopregnanolone
The following data is based on the product molecular weight 318.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.14 mL | 15.70 mL | 31.40 mL |
| 5 mM | 0.63 mL | 3.14 mL | 6.28 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.14 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Belelli and Lambert Neurosteroids: endogenous regulators of the GABAA receptor. Nat.Rev.Neurosci. 2005 PMID: 15959466
- Agis-Balboa Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc.Natl.Acad.Sci.USA
- Puia Neurosteroids act on recombinant human GABAA receptors. Neuron 1990 PMID: 2160838
Product Specific Notices for Allopregnanolone
For research use only
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