Aliskiren hemifumarate

Name: Aliskiren hemifumarate
Brand: Tocris Bioscience
SKU: 5491

Tocris Bioscience, part of Bio-Techne | Catalog # 5491

Citations (1)

COA / SDS

Potent renin inhibitor; antihypertensive

Key Product Details

Description:	Potent renin inhibitor; antihypertensive
Alternative Names:	SPP 100
Chemical Name:	(αS,γS,δS,ζS)-δ-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)benzeneoctanamide hemifumarate
Purity:	≥98% (HPLC)
Molecular Weight:	609.83

View Full Technical Details for Aliskiren hemifumarate

Technical Data
Citations

Biological Activity for Aliskiren hemifumarate

Aliskiren hemifumarate is a potent renin inhibitor (IC₅₀ = 0.6 and 80 nM for human and rat respectively). Exhibits selectivity for renin over a range of other aspartic proteinases (>5000 nM). Lowers blood pressure in a hypertensive rodent model. Orally active.

Compound Libraries for Aliskiren hemifumarate

Aliskiren hemifumarate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Aliskiren hemifumarate

M. Wt	609.83
Formula	C₃₀H₅₃N₃O6.1/2C₄H₄O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	173334-58-2
PubChem ID	6918427
InChi Key	KLRSDBSKUSSCGU-KRQUFFFQSA-N
Smiles	COC1=C(OCCCOC)C=C(C[C@H]([C@@H](C)C)C[C@@H]([C@@H](O)C[C@@H]([C@@H](C)C)C(NCC(C)(C)C(N)=O)=O)N)C=C1.COC2=C(OCCCOC)C=C(C[C@H]([C@@H](C)C)C[C@@H]([C@@H](O)C[C@@H]([C@@H](C)C)C(NCC(C)(C)C(N)=O)=O)N)C=C2.O=C(/C=C/C(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Aliskiren hemifumarate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	60.98	100
	DMSO	60.98	100

Preparing Stock Solutions for Aliskiren hemifumarate

The following data is based on the product molecular weight 609.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.64 mL	8.20 mL	16.40 mL
5 mM	0.33 mL	1.64 mL	3.28 mL
10 mM	0.16 mL	0.82 mL	1.64 mL
50 mM	0.03 mL	0.16 mL	0.33 mL

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References for Aliskiren hemifumarate

References are publications that support the biological activity of the product.

Kaye and Krum Drug discovery for heart failure: a new era or the end of the pipeline? Nat.Rev.Drug Discov. 2007 PMID: 17268484
Jensen Aliskiren: the first renin inhibitor for clinical treatment. Nat.Rev.Drug Discov. 2 PMID: 18340340