Aliskiren hemifumarate
Tocris Bioscience, part of Bio-Techne | Catalog # 5491
Potent renin inhibitor; antihypertensive
Key Product Details
Description
Potent renin inhibitor; antihypertensive
Alternative Names
SPP 100
Product Description
Aliskiren hemifumarate is a potent renin inhibitor (IC50 = 0.6 and 80 nM for human and rat respectively). Exhibits selectivity for renin over a range of other aspartic proteinases (>5000 nM). Lowers blood pressure in a hypertensive rodent model. Orally active.Product Specifications
Molecular Weight
609.83
Formula
C30H53N3O6.1/2C4H4O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(αS,γS,δS,ζS)-δ-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)benzeneoctanamide hemifumarate
CAS Number
173334-58-2
PubChem ID
6918427
InChI Key
KLRSDBSKUSSCGU-KRQUFFFQSA-N
SMILES
COC1=C(OCCCOC)C=C(C[C@H]([C@@H](C)C)C[C@@H]([C@@H](O)C[C@@H]([C@@H](C)C)C(NCC(C)(C)C(N)=O)=O)N)C=C1.COC2=C(OCCCOC)C=C(C[C@H]([C@@H](C)C)C[C@@H]([C@@H](O)C[C@@H]([C@@H](C)C)C(NCC(C)(C)C(N)=O)=O)N)C=C2.O=C(/C=C/C(O)=O)O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 60.98 | 100 | |
| DMSO | 60.98 | 100 |
Preparing Stock Solutions
for Aliskiren hemifumarate
The following data is based on the product molecular weight 609.83
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.64 mL | 8.20 mL | 16.40 mL |
| 5 mM | 0.33 mL | 1.64 mL | 3.28 mL |
| 10 mM | 0.16 mL | 0.82 mL | 1.64 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.33 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kaye and Krum Drug discovery for heart failure: a new era or the end of the pipeline? Nat.Rev.Drug Discov. 2007 PMID: 17268484
- Jensen Aliskiren: the first renin inhibitor for clinical treatment. Nat.Rev.Drug Discov. 2 PMID: 18340340
Product Specific Notices for Aliskiren hemifumarate
For research use only
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