AKOS 022
Tocris Bioscience, part of Bio-Techne | Catalog # 7135
Voltage-dependent anion channel (VDAC) inhibitor
Key Product Details
Description
Voltage-dependent anion channel (VDAC) inhibitor
Product Description
AKOS 022 is a voltage-dependent anion channel (VDAC; Kd = 154 μM) inhibitor, which reduces channel conductance. In HEK-293 cells, AKOS 022 inhibits selenium-induced VDAC oligomerization, cytochrome C release from mitochondria and apoptosis (IC50 values range from 3.3 to 3.6 μM). AKOS 022 also prevents glucotoxicity-mediated overexpression of VDAC1 in INS-1 cells.Product Specifications
Molecular Weight
467.87
Formula
C22H21ClF3N3O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-(4-Chlorophenyl)-3-[4-[[4-(trifluoromethoxy)phenyl]amino]-1-piperidinyl]-2,5-pyrrolidinedione
CAS Number
878983-38-1
PubChem ID
5304523
InChI Key
ZZVCWIMICOFQNJ-UHFFFAOYSA-N
SMILES
FC(F)(OC1=CC=C(C=C1)NC2CCN(C3CC(N(C4=CC=C(C=C4)Cl)C3=O)=O)CC2)F
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.79 | 100 |
Preparing Stock Solutions
for AKOS 022
The following data is based on the product molecular weight 467.87
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.14 mL | 10.69 mL | 21.37 mL |
| 5 mM | 0.43 mL | 2.14 mL | 4.27 mL |
| 10 mM | 0.21 mL | 1.07 mL | 2.14 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhang Preserving insulin secretion in diabetes by inhibiting VDAC1 overexpression and surface translocation in β cells. Cell Metab. 2019 PMID: 30293774
- Ben-Hail Novel compounds targeting the mitochondrial protein VDAC1 inhibit apoptosis and protect against mitochondrial dysfunction. J.Biol.Chem. 2016 PMID: 27738100
Product Specific Notices for AKOS 022
For research use only
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