AGN 192403 hydrochloride

Name: AGN 192403 hydrochloride
Brand: Tocris Bioscience
SKU: 1072

Catalog # 1072 | Tocris Bioscience a Bio-Techne Brand

Citations (2)

COA / SDS

I1 selective ligand

Key Product Details

Description:	I₁ selective ligand
Alternative Names:	BRD4780
Chemical Name:	(±)-2-endo-Amino-3-exo-isopropylbicyclo[2.2.1]heptane hydrochloride
Molecular Weight:	189.73

View Full Technical Details for AGN 192403 hydrochloride

Technical Data
Citations (2) / Reviews

Biological Activity for AGN 192403 hydrochloride

AGN 192403 hydrochloride is an i₁ imidazoline binding site selective ligand with a potency at I₁ comparable to moxonidine, but devoid of affinity for adrenoceptors and the I₂ binding site. Causes none of the physiological responses associated with the I₁ binding site in animal models. Also binds TMED9 cargo receptor. Releases MUC1-fs from TMED9 containing vesicles in kidney cells bearing MUC1 gene mutation

Technical Data for AGN 192403 hydrochloride

M. Wt	189.73
Formula	C₁₀H₁₉N.HCl
Storage	Store at RT
CAS Number	1021868-90-5
PubChem ID	11957452
InChi Key	KSTGYMXUFHCTSM-UHFFFAOYSA-N
Smiles	Cl.CC(C)C1C(C2CC1CC2)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AGN 192403 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions for AGN 192403 hydrochloride

The following data is based on the product molecular weight 189.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.27 mL	26.35 mL	52.71 mL
5 mM	1.05 mL	5.27 mL	10.54 mL
10 mM	0.53 mL	2.64 mL	5.27 mL
50 mM	0.11 mL	0.53 mL	1.05 mL

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References for AGN 192403 hydrochloride

References are publications that support the biological activity of the product.

Dvela-Levitt Small molecule targets TMED9 and promotes lysosomal degradation to reverse proteinopathy. Cell 2019 PMID: 31348885
Mukaddam-Daher Receptors involved in moxonidine-stimulated strial natriuretic peptide released from isolated normotensive rat hearts. Eur.J.Pharmacol. 2006 PMID: 16774751
Raasch Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction. Br.J.Pharmacol. 2002 PMID: 11834614
Munk Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline₁ receptor specific agent. J.Med.Chem. 1996 PMID: 8632424

Citations for AGN 192403 hydrochloride (2)

Showing 1 - 2 of 2 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for AGN 192403 hydrochloride include:

Dvela-Levitt et al. (2019) Small molecule targets TMED9 and promotes lysosomal degradation to reverse proteinopathy. Cell. 178:521
PMID: 31348885
Sánchez-Blázquez et al. (2000) Activation of I(2)-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol. 130:146
PMID: 10781010

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