AGI 5198
Tocris Bioscience, part of Bio-Techne | Catalog # 7087
Potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1)
Key Product Details
Description
Potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1)
Product Description
AGI 5198 is a potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1; IC50 = 70 nM). Selective for mIDH1 over wild-type IDH1 and IDH2. Inhibits production of oncometabolite D-2 hydroxyglutarate. Attenuates growth of glioma cells containing mIDH1, but not wild-type IDH1, in vitro and in vivo. Also inhibits growth of fibrosarcoma and chondrosarcoma cells bearing mIDH1.Product Specifications
Molecular Weight
462.56
Formula
C27H31FN4O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-(Cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1H-Imidazole-1-acetamide
CAS Number
1355326-35-0
PubChem ID
56645356
InChI Key
FNYGWXSATBUBER-UHFFFAOYSA-N
SMILES
CC1=NC=CN1CC(=O)N(C(C(=O)NC1CCCCC1)C1=C(C)C=CC=C1)C1=CC(F)=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.13 | 50 | |
| Ethanol | 4.63 | 10 |
Preparing Stock Solutions
for AGI 5198
The following data is based on the product molecular weight 462.56
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.32 mL | 21.62 mL | 43.24 mL |
| 2.5 mM | 0.86 mL | 4.32 mL | 8.65 mL |
| 5 mM | 0.43 mL | 2.16 mL | 4.32 mL |
| 25 mM | 0.09 mL | 0.43 mL | 0.86 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Li Treatment with a small molecule mutant IDH1 inhibitor suppresses tumorigenic activity and decreases production of the oncometabolite 2-hydroxyglutarate in human chondrosarcoma cells. PLoS ONE 2015 PMID: 26368816
- Badur Oncogenic R132 IDH1 mutations limit NADPH for de novo lipogenesis through (D)2-hydroxyglutarate production in fibrosarcoma cells. Cell Rep. 2018 PMID: 30355481
- Rohle An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science 2013 PMID: 23558169
Product Specific Notices for AGI 5198
For research use only
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