Tocris Bioscience a Bio-Techne Brand
Key Product Details
|Description:||EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor|
|Alternative Names:||Tyrphostin AG 490|
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Citations for AG 490 (14)
Citations are publications that use Bio-Techne products. Selected citations for AG 490 include:
Azad et al.
PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy.
EMBO Mol Med.
Tactacan et al.
The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling.
Zhao et al.
Evodiamine Induces Apoptosis and Inhibits Migration of HCT-116 Human Colorectal Cancer Cells.
J Transl Med.
Jiang et al.
YangZheng XiaoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cells.
Shenoy et al.
Let-7 and miR-125 cooperate to prime progenitors for astrogliogenesis.
Rogers and Gahring
Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways.
Kubota et al.
mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
Park et al.
Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging.
Doulatov et al.
PLZF is a regulator of homeostatic and cytokine-induced myeloid development.
Jung et al.
Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells.
Fontaine et al.
IL-9/IL-9 receptor signaling selectively protects cortical neurons against developmental apoptosis.
Cell Death Differ.
Lu et al.
JAK/STAT and PI3K/AKT pathways form a mutual transactivation loop and afford resistance to oxidative stress-induced apoptosis in cardiomyocytes.
Cell Physiol Biochem.
Gross et al.
The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta.
Am J Physiol Heart Circ Physiol.
Bellik et al.
Intracellular pathways triggered by the selective FLT-1-agonist placental growth factor in vascular smooth muscle cells exposed to hypoxia.
Br J Pharmacol.
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