Key Product Details
Description: | EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor |
Alternative Names: | Tyrphostin AG 490 |
Chemical Name: | (E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 294.31 |
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Citations for AG 490 (14)
Citations are publications that use Bio-Techne products. Selected citations for AG 490 include:
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Azad et al.
(2017)
PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy.
EMBO Mol Med.
9:167
PMID: 27932443 -
Tactacan et al.
(2015)
The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling.
Mol Cancer.
14:139
PMID: 26215634 -
Zhao et al.
(2015)
Evodiamine Induces Apoptosis and Inhibits Migration of HCT-116 Human Colorectal Cancer Cells.
J Transl Med.
16:27411
PMID: 26580615 -
Jiang et al.
(2015)
YangZheng XiaoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cells.
PLoS One.
13:280
PMID: 26310485 -
Shenoy et al.
(2015)
Let-7 and miR-125 cooperate to prime progenitors for astrogliogenesis.
Neuropsychopharmacology.
34:1180
PMID: 25715649 -
Rogers and Gahring
(2015)
Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways.
EMBO J.
10:e0143319
PMID: 26619345 -
Kubota et al.
(2014)
mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
PLoS One.
9:e106316
PMID: 25181481 -
Park et al.
(2013)
Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging.
Neuron.
38:1426
PMID: 23389690 -
Doulatov et al.
(2009)
PLZF is a regulator of homeostatic and cytokine-induced myeloid development.
Genes Dev.
23:2076
PMID: 19723763 -
Jung et al.
(2008)
Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells.
Carcinogenesis.
29:713
PMID: 18258605 -
Fontaine et al.
(2008)
IL-9/IL-9 receptor signaling selectively protects cortical neurons against developmental apoptosis.
Cell Death Differ.
15:1542
PMID: 18551134 -
Lu et al.
(2008)
JAK/STAT and PI3K/AKT pathways form a mutual transactivation loop and afford resistance to oxidative stress-induced apoptosis in cardiomyocytes.
Cell Physiol Biochem.
21:305
PMID: 18441519 -
Gross et al.
(2006)
The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta.
Am J Physiol Heart Circ Physiol.
291:H827
PMID: 16517948 -
Bellik et al.
(2005)
Intracellular pathways triggered by the selective FLT-1-agonist placental growth factor in vascular smooth muscle cells exposed to hypoxia.
Br J Pharmacol.
146:568
PMID: 16086034
There are no citations that match your criteria.