Adenine

Name: Adenine
Brand: Tocris Bioscience
SKU: 4202

Tocris Bioscience, part of Bio-Techne | Catalog # 4202

Citations (52)

COA / SDS

Adenine receptor agonist

Key Product Details

Description:	Adenine receptor agonist
Chemical Name:	6-Aminopurine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	171.59

View Full Technical Details for Adenine

Technical Data
Citations

Biological Activity for Adenine

Adenine is a high affinity adenine receptor agonist (K_i = 18 nM at rat adenine receptor). Inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor; also stimulates GTPγS binding (pEC₅₀ values are 8.54 and 7.21 respectively).

Technical Data for Adenine

M. Wt	171.59
Formula	C₅H₅N₅.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	2922-28-3
PubChem ID	76219
InChi Key	UQVDQSWZQXDUJB-UHFFFAOYSA-N
Smiles	NC1=C2C(NC=N2)=NC=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Adenine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	17.16	100
	DMSO	17.16	100

Preparing Stock Solutions for Adenine

The following data is based on the product molecular weight 171.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.83 mL	29.14 mL	58.28 mL
5 mM	1.17 mL	5.83 mL	11.66 mL
10 mM	0.58 mL	2.91 mL	5.83 mL
50 mM	0.12 mL	0.58 mL	1.17 mL

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Reconstitution Calculator

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References for Adenine

References are publications that support the biological activity of the product.

Bender Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc.Natl.Acad.Sci.
Gorzalka Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues. Mol.Pharmacol. 2005 PMID: 15604413