Adaptaquin

Tocris Bioscience, part of Bio-Techne | Catalog # 5953

HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant
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Key Product Details

Description

HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant

View all Hydrolase Inhibitors »

Product Description

Adaptaquin is a HIF-prolyl hydroxylase-2 (PHD2) inhibitor. Blocks glutamate induced ROS production in HT-22 cells, independent of MnSOD. Exhibits neuroprotective effects and enhances functional recovery in rodent intracerebral hemorrhage models, via inhibition of ATF4 dependent genes. Brain penetrant. Also antioxidant.

Product Specifications

Molecular Weight

377.82

Formula

C21H16ClN3O2

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol

CAS Number

385786-48-1

PubChem ID

3740671

InChI Key

KKYHNYRUBSYTCZ-UHFFFAOYSA-N

SMILES

OC1=C(N=CC=C1)NC(C2=C(C3=C(C=C2)C=CC=N3)O)C4=CC=C(C=C4)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.78 100

Preparing Stock Solutions for Adaptaquin

The following data is based on the product molecular weight 377.82

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.23 mL 26.47 mL
5 mM 0.53 mL 2.65 mL 5.29 mL
10 mM 0.26 mL 1.32 mL 2.65 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Adaptaquin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Adaptaquin

For research use only

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