ACTH (1-39)

Name: ACTH (1-39)
Brand: Tocris Bioscience
SKU: 3492

Tocris Bioscience a Bio-Techne Brand

Catalog # 3492

Citations (3)

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Key Product Details

Description:	Potent endogenous MC₂ agonist
Alternative Names:	Adrenocorticotropic hormone (1-39)
Purity:	≥95% (HPLC)
Molecular Weight:	4541.1

View Full Technical Details for ACTH (1-39)

Biological Activity for ACTH (1-39)

ACTH (1-39) is a potent endogenous melanocortin receptor 2 (MC₂) agonist (EC₅₀ = 57 pM). Component of the hypothalamic-pituitary-adrenal (HPA) axis that stimulates glucocorticoid production and release from the adrenal cortex. Induces insulin resistance, promotes a proinflammatory profile and stimulates UCP-1 in adipocytes in vitro.

Technical Data for ACTH (1-39)

M. Wt	4541.1
Formula	C₂₀₇H₃₀₈N₅₆O₅₈S
Single Letter Sequence	SYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEF
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	12279-41-3
PubChem ID	90488852
InChi Key	KNOZNCXWNQVSDB-LAZPIJHFSA-N
Smiles	[H]N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ACTH (1-39)

Solubility

Soluble to 1mg/ml in water

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References for ACTH (1-39)

References are publications that support the biological activity of the product.

Bertolini Brain effects of melanocortins. Pharmacol.Res. 2009 PMID: 18996199
Iwen Melanocortin crosstalk with adipose functions: ACTH directly induces Ins resistance, promotes a pro-inflammatory adipokine profile and stimulates UCP-1 in adipocytes. J.Endocrinol. 2008 PMID: 18310442
Kapas Agonist and receptor binding properties of adrenocorticotropin peptides using the cloned mouse adrenocorticotropin receptor expressed in a stably transfected HeLa cell line. Endocrinology 1996 PMID: 8754753

Citations for ACTH (1-39) (3)

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Citations are publications that use Bio-Techne products. Selected citations for ACTH (1-39) include:

Nepomuceno et al. (2018) Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro. Front Pharmacol. 9:157
PMID: 29599718
Nøhr et al. (2017) The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. Neurochem Int. 102:105
PMID: 27916541
Martineau et al. (2014) The atherogenic Scarb1 null mouse model shows a high bone mass phenotype. Am J Physiol Endocrinol Metab. 306:E48
PMID: 24253048

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Product Documents for ACTH (1-39)

COA

Certificate of Analysis

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