ACDPP hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2254
Selective mGlu5 antagonist
Discontinued Product
2254 has been discontinued.
View all Group I mGluR Antagonists products.
Product Description
Antagonist at the mGlu5 receptor (Ki = 295 nM). Inhibits human mGlu5 receptor-mediated calcium flux with an IC50 of 134 nM.Product Specifications
Molecular Weight
329.19
Formula
C12H13ClN6O.HCl
Storage
Desiccate at RT
Purity
≥99% (HPLC)
Chemical Name
3-Amino-6-chloro-5-dimethylamino-N-2-pyridinylpyrazinecarboxamide hydrochloride
PubChem ID
16759168
InChI Key
CXIHLPLRTFPHKX-UHFFFAOYSA-N
SMILES
Cl.CN(C)C1=C(Cl)N=C(C(=O)NC2=CN=CC=C2)C(N)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.92 | 100 |
Preparing Stock Solutions
for ACDPP hydrochloride
The following data is based on the product molecular weight 329.19
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.04 mL | 15.19 mL | 30.38 mL |
| 5 mM | 0.61 mL | 3.04 mL | 6.08 mL |
| 10 mM | 0.30 mL | 1.52 mL | 3.04 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.61 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wang Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors. J.Neurosci. 2008 PMID: 18434517
- Bonnefous Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists. Bioorg.Med.Chem.Lett. 2005 PMID: 15686941
Product Specific Notices for ACDPP hydrochloride
For research use only
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