Acarbose
Tocris Bioscience, part of Bio-Techne | Catalog # 2673
Glucosidase α inhibitor (intestinal)
Key Product Details
Description
Glucosidase α inhibitor (intestinal)
Alternative Names
Bay-g 5421
Product Description
Acarbose is an inhibitor of intestinal α-glucosidase (IC50 = 11 nM). Antidiabetic; inhibits the hydrolysis of complex carbohydrates.Product Specifications
Molecular Weight
645.25
Formula
C25H43NO18
Storage
Desiccate at RT
Chemical Name
O-4,6-Dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-α-D-glucopyranosyl-(1-4)-O-α-D-glucopyranosyl-(1-4)-D-Glucose
CAS Number
56180-94-0
PubChem ID
444254
InChI Key
XUFXOAAUWZOOIT-SXARVLRPSA-N
SMILES
C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 64.52 | 100 | |
| DMSO | 64.52 | 100 |
Preparing Stock Solutions
for Acarbose
The following data is based on the product molecular weight 645.25
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.55 mL | 7.75 mL | 15.50 mL |
| 5 mM | 0.31 mL | 1.55 mL | 3.10 mL |
| 10 mM | 0.15 mL | 0.77 mL | 1.55 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.31 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Balfour and McTavish Acarbose: an update of its pharmacology and therapeutic use in diabetes mellitus. Drugs 1993 PMID: 7510610
- Oki Evaluation of alpha-glucosidase inhibition by using an immobilized assay system. Biol.Pharm.Bull. 2000 PMID: 10993209
- Krause Inhibition of disaccharide digestion in rat intestine by the alpha-glucosidase inhibitor aca. (BAY g 5421). Digestion 1982 PMID: 6754513
Product Specific Notices for Acarbose
For research use only
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