AC 5216
Tocris Bioscience, part of Bio-Techne | Catalog # 5281
Selective TSPO ligand
Key Product Details
Description
Selective TSPO ligand
Alternative Names
XBD173
Product Description
AC 5216 is a ligand of translocator protein (TSPO, peripheral benzodiazepine receptor). Exhibits high affinity for TSPO in rat whole brain (Ki = 0.297 nM), and high potency against human and rat glial TSPO (IC50 values are 2.73 and 3.04 nM respectively). Displays no noticeable binding to a number of other receptors, transporters or ion channels. Also displays anxiolytic and antidepressant effects in rodent models, without inducing benzodiazepine-like adverse effects.Product Specifications
Molecular Weight
401.46
Formula
C23H23N5O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-Ethyl-7,8-dihydro-7-methyl-8-oxo-2-phenyl-N-(phenylmethyl)-9H-purine-9-acetamide
CAS Number
226954-04-7
PubChem ID
6433109
InChI Key
NBMBIEOUVBHEBM-UHFFFAOYSA-N
SMILES
O=C(N1C)N(CC(N(CC)CC2=CC=CC=C2)=O)C3=C1C=NC(C4=CC=CC=C4)=N3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.15 | 100 |
Preparing Stock Solutions
for AC 5216
The following data is based on the product molecular weight 401.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.49 mL | 12.45 mL | 24.91 mL |
| 5 mM | 0.50 mL | 2.49 mL | 4.98 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.49 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Qiu Repeated administration of AC-5216, a ligand for the 18kDa translocator protein, improves behavioral deficits in a mouse model of post-traumatic stress disorder. Prog.Neuropsychopharmacol.Biol.Psychiatry 2013 PMID: 23624119
- Kita Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand. Br.J.Pharmacol. 2004 PMID: 15249420
Product Specific Notices for AC 5216
For research use only
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