ABT 639
Tocris Bioscience, part of Bio-Techne | Catalog # 6770
CaV3.2 and CaV3.1 channel blocker; orally bioavailable
Key Product Details
Description
CaV3.2 and CaV3.1 channel blocker; orally bioavailable
Product Description
ABT 639 is a CaV3.2 channel blocker (IC50 = 2.3 μM). Also blocks low voltage-activated (CaV3.1) currents in native rat DRG neurons (IC50 = 7.6 μM). Exhibits little or no activity at other ion channels and receptors. Displays antinociceptive effects in a mechanical hyperalgesia model in vivo. Orally bioavailable.Product Specifications
Molecular Weight
455.91
Formula
C20H20ClF2N3O3S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide
CAS Number
1235560-28-7
PubChem ID
46851313
InChI Key
AGPIHNZOZNKRGT-CYBMUJFWSA-N
SMILES
[H][C@]12CCCN1CCN(C(C3=CC(S(=O)(NC4=C(C=CC=C4)F)=O)=C(C=C3Cl)F)=O)C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.12 | 20 |
Preparing Stock Solutions
for ABT 639
The following data is based on the product molecular weight 455.91
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 10.97 mL | 54.84 mL | 109.67 mL |
| 1 mM | 2.19 mL | 10.97 mL | 21.93 mL |
| 2 mM | 1.10 mL | 5.48 mL | 10.97 mL |
| 10 mM | 0.22 mL | 1.10 mL | 2.19 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhang Optimization of ADME properties for sulfonamides leading to the discovery of a T-type calcium channel blocker, ABT-639. ACS Med.Chem.Lett. 2015 PMID: 26101566
Product Specific Notices for ABT 639
For research use only
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