A12B4C3
Tocris Bioscience, part of Bio-Techne | Catalog # 5097
Potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor
Key Product Details
Description
Potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor
Product Description
A12B4C3 is a potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor (IC50 = 60 nM). Displays no effect on calcineurin, protein PP-1 or APTX. Interrupts DNA repair and enhances radiosensitivity of human A549 lung carcinoma and MDA-MB-231 cells.Product Specifications
Molecular Weight
534.65
Formula
C30H38N4O5
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4a,7a-Dihydro-2-(1-hydroxyundecyl)-1-[(4-nitrophenyl)amino]-6-phenyl-1H-pyrrolo[3,4-b]pyridine-5,7(2H,6H)-dione
CAS Number
1005129-80-5
PubChem ID
6610064
InChI Key
KVHGJAKTBPFFNV-UHFFFAOYSA-N
SMILES
O=C2N(C4=CC=CC=C4)C(C1C=CC(C(O)CCCCCCCCCC)N(NC3=CC=C([N+]([O-])=O)C=C3)C12)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.47 | 100 |
Preparing Stock Solutions
for A12B4C3
The following data is based on the product molecular weight 534.65
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.87 mL | 9.35 mL | 18.70 mL |
| 5 mM | 0.37 mL | 1.87 mL | 3.74 mL |
| 10 mM | 0.19 mL | 0.94 mL | 1.87 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.37 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Freschauf Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase. J.Biol.Chem. 2010 PMID: 19940137
- Schellenberg DNA end processing by polynucleotide kinase/phosphatase. Proc.Natl.Acad.Sci.U.S.A. 2011 PMID: 22184240
- Freschauf Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase. Cancer Res. 2009 PMID: 19773431
Product Specific Notices for A12B4C3
For research use only
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