α-CGRP (human)

Name: α -CGRP (human)
Brand: Tocris Bioscience
SKU: 3012
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3012

(1)

Citations (2)

COA / SDS

CGRP agonist

Key Product Details

Description:	CGRP agonist
Purity:	≥95% (HPLC)
Molecular Weight:	3789.33

View Full Technical Details for α-CGRP (human)

Technical Data
Citations / Reviews (1)

Biological Activity for α-CGRP (human)

α-CGRP (human) is an endogenous calcitonin gene-related peptide receptor (CGRP) agonist. It is a long-lasting vasodilator. α-CGRP (human) also reduces the secretion of both mouse Ins1 and Ins2 proteins and remodels amylin fibrillization in mouse pancreatic β-cells.

Technical Data for α-CGRP (human)

M. Wt	3789.33
Formula	C₁₆₃H₂₆₇N₅₁O₄₉S₂
Single Letter Sequence	ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF (Modifications: Phe-37 = C-terminal amide, Disulfide bridge: 2-7)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	90954-53-3
PubChem ID	44563440
InChi Key	JMJJWZFCOWFIBU-XJVRLEFXSA-N
Smiles	[H]N[C@@H](C)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC1=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for α-CGRP (human)

Solubility

Soluble to 0.5mg/ml in water

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for α-CGRP (human)

References are publications that support the biological activity of the product.

Gray α-CGRP disrupts amylin fibrillization and regulates insulin secretion: implications on diabetes and migraine. Chem.Sci. 2021 PMID: 34168810
Kee The role of calcitonin gene related peptide (CGRP) in neurogenic vasodilation and its cardioprotective effects. Front Physiol. 2018 PMID: 30283343
Poyner International union of pharmacology XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol.Revs.