α-CGRP (human)

Name: α -CGRP (human)
Brand: Tocris Bioscience
SKU: 3012
Rating: 5 (1 reviews)

Catalog # 3012 | Tocris Bioscience a Bio-Techne Brand

(1)

COA / SDS

CGRP agonist

Key Product Details

Description:	CGRP agonist
Purity:	≥95% (HPLC)
Molecular Weight:	3789.33

View Full Technical Details for α-CGRP (human)

Technical Data
Citations / Reviews (1)

Biological Activity for α-CGRP (human)

α-CGRP (human) is an endogenous calcitonin gene-related peptide receptor (CGRP) agonist. It is a long-lasting vasodilator. α-CGRP (human) also reduces the secretion of both mouse Ins1 and Ins2 proteins and remodels amylin fibrillization in mouse pancreatic β-cells.

Technical Data for α-CGRP (human)

M. Wt	3789.33
Formula	C₁₆₃H₂₆₇N₅₁O₄₉S₂
Single Letter Sequence	ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF (Modifications: Phe-37 = C-terminal amide, Disulfide bridge: 2-7)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	90954-53-3
PubChem ID	44563440
InChi Key	JMJJWZFCOWFIBU-XJVRLEFXSA-N
Smiles	[H]N[C@@H](C)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC1=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for α-CGRP (human)

Solubility

Soluble to 0.5mg/ml in water

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References for α-CGRP (human)

References are publications that support the biological activity of the product.

Gray α-CGRP disrupts amylin fibrillization and regulates insulin secretion: implications on diabetes and migraine. Chem.Sci. 2021 PMID: 34168810
Kee The role of calcitonin gene related peptide (CGRP) in neurogenic vasodilation and its cardioprotective effects. Front Physiol. 2018 PMID: 30283343
Poyner International union of pharmacology XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol.Revs.

Citations for α-CGRP (human)

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Customer Reviews for α-CGRP (human) (1)

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Potent CGRP agonist

Name: Anonymous

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: Hek 293 Cells

in in vitro study (Hek 293 cells), stimulate CGRP Receptor (CLR) on the plasma membrane causing internalization.

Easy to dissolve in DMSO, stock solution concentration 10mM.

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