A 803467

Name: A 803467
Brand: Tocris Bioscience
SKU: 2976

Catalog # 2976 | Tocris Bioscience a Bio-Techne Brand

Citations (7)

COA / SDS

Selective NaV1.8 channel blocker

Key Product Details

Description:	Selective Na_V1.8 channel blocker
Chemical Name:	5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	357.79

View Full Technical Details for A 803467

Technical Data
Citations (7) / Reviews

Biological Activity for A 803467

A 803467 is a selective blocker of Na_V1.8 channels (IC₅₀ values are 8, 2450, 6740, 7340 and 7380 nM for hNa_V1.8, hNa_V1.3, hNa_V1.7, hNa_V1.5 and hNa_V1.2 channels respectively). Shows no significant activity against TRPV1, P2X_2/3, Ca_V2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.

Compound Libraries for A 803467

A 803467 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for A 803467

M. Wt	357.79
Formula	C₁₉H₁₆ClNO₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	944261-79-4
PubChem ID	16038374
InChi Key	VHKBTPQDHDSBSP-UHFFFAOYSA-N
Smiles	ClC(C=C2)=CC=C2C1=CC=C(C(NC3=CC(OC)=CC(OC)=C3)=O)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 803467

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.78	100
	ethanol	8.94	25

Preparing Stock Solutions for A 803467

The following data is based on the product molecular weight 357.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.79 mL	13.97 mL	27.95 mL
5 mM	0.56 mL	2.79 mL	5.59 mL
10 mM	0.28 mL	1.40 mL	2.79 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for A 803467

References are publications that support the biological activity of the product.

McGaraughty A selective NaV1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats. J.Pharmacol.Exp.Ther. 2008 PMID: 18089840
Kort Discovery and biological evaluation of 5-Aryl-2-furfuramides, potent and selective blockers of the Na_v1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain. J.Med.Chem. 2008 PMID: 18176998
Rush and Cummins Painful research: identification of a small-molecule inhibitor that selectively targets Na_V1.8 sodium channels. Mol.Interv. 2007 PMID: 17827438
Jarvis A-803467, a potent and selective Na_V1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc.Natl.Acad.Sci. 2007 PMID: 17483457

Citations for A 803467 (7)

Showing 1 - 7 of 7 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for A 803467 include:

Wu et al. (2016) CXCL13/CXCR5 enhances sodium channel Nav1.8 current density via p38 MAP kinase in primary sensory neurons following inflammatory pain Scientific Reports. 6:34836
PMID: 27708397
Curtright et al. (2015) Modeling nociception in zebrafish: a way forward for unbiased analgesic discovery. PLoS One. 10:e0116766
PMID: 25587718
Mascanfroni et al. (2015) Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α. Biol Open. 21:638
PMID: 26005855
Liu et al. (2014) Functional upregulation of nav1.8 sodium channels on the membrane of dorsal root Ganglia neurons contributes to the development of cancer-induced bone pain. PLoS One. 9:e114623
PMID: 25503076
Stone et al. (2013) Attenuation of autonomic reflexes by A803467 may not be solely caused by blockade of NaV 1.8 channels. Nat Med. 543:177
PMID: 23523647
Schuelert and McDougall (2012) Involvement of Nav 1.8 sodium ion channels in the transduction of mechanical pain in a rodent model of osteoarthritis. Arthritis Res Ther. 14:R5
PMID: 22225591
Bladen (2012) Common mechanisms of drug interactions with sodium and T-type calcium channels. Mol Pharmacol. 82:481
PMID: 22695716

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