A 803467

Tocris Bioscience, part of Bio-Techne | Catalog # 2976

Selective NaV1.8 channel blocker
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Key Product Details

Description

Selective NaV1.8 channel blocker

View all Voltage-gated Sodium Channel Blockers »

Product Description

A 803467 is a selective blocker of NaV1.8 channels (IC50 values are 8, 2450, 6740, 7340 and 7380 nM for hNaV1.8, hNaV1.3, hNaV1.7, hNaV1.5 and hNaV1.2 channels respectively). Shows no significant activity against TRPV1, P2X2/3, CaV2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.

Product Specifications

Molecular Weight

357.79

Formula

C19H16ClNO4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide

CAS Number

944261-79-4

PubChem ID

16038374

InChI Key

VHKBTPQDHDSBSP-UHFFFAOYSA-N

SMILES

ClC(C=C2)=CC=C2C1=CC=C(C(NC3=CC(OC)=CC(OC)=C3)=O)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.78 100
Ethanol 8.94 25

Preparing Stock Solutions for A 803467

The following data is based on the product molecular weight 357.79

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.79 mL 13.97 mL 27.95 mL
5 mM 0.56 mL 2.79 mL 5.59 mL
10 mM 0.28 mL 1.40 mL 2.79 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Calculators

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Product Documents for A 803467

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for A 803467

For research use only

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