A 784168

Name: A 784168
Brand: Tocris Bioscience
SKU: 4319

Tocris Bioscience, part of Bio-Techne | Catalog # 4319

Citations (15)

COA / SDS

Potent and selective TRPV1 antagonist

Key Product Details

Description:	Potent and selective TRPV1 antagonist
Chemical Name:	3,6-Dihydro-3'-(trifluoromethyl)-N-[4-[(trifluoromethyl)sulfonyl]phenyl]-[1(2H),2'-bipyridine]-4-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	479.4

View Full Technical Details for A 784168

Technical Data
Citations

Biological Activity for A 784168

A 784168 is a potent TRPV1 antagonist (IC₅₀ = 25 nM for inhibition of TRPV1 activation by 50 nM capsaicin). Displays no activity against a range of receptors, including TRPA1, GABA, opioid, and purinergic receptors.

Compound Libraries for A 784168

A 784168 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for A 784168

M. Wt	479.4
Formula	C₁₉H₁₅F₆N₃O₃S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	824982-41-4
PubChem ID	11420211
InChi Key	SDUAWRFBHRAFBM-UHFFFAOYSA-N
Smiles	O=C(NC3=CC=C(S(=O)(C(F)(F)F)=O)C=C3)C(CC2)=CCN2C1=C(C(F)(F)F)C=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 784168

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	47.94	100
	ethanol	23.97	50

Preparing Stock Solutions for A 784168

The following data is based on the product molecular weight 479.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.09 mL	10.43 mL	20.86 mL
5 mM	0.42 mL	2.09 mL	4.17 mL
10 mM	0.21 mL	1.04 mL	2.09 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for A 784168

References are publications that support the biological activity of the product.

Cui TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists. J.Neurosci. 2006 PMID: 16971522
Bianchi [³H]-A-778317 [1-((R-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor. J.Pharmacol.Exp.Ther. 2007 PMID: 17660385