A 779

Name: A 779
Brand: Tocris Bioscience
SKU: 5937

Tocris Bioscience, part of Bio-Techne | Catalog # 5937

Citations (15)

COA / SDS

Selective Mas receptor (Ang-(1-7) receptor) antagonist

Key Product Details

Description:	Selective Mas receptor (Ang-(1-7) receptor) antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	872.98

View Full Technical Details for A 779

Technical Data
Citations

Biological Activity for A 779

A 779 is a selective Mas receptor (Ang-(1-7) receptor) antagonist. Exhibits no significant affinity for AT₁ or AT₂ receptors at a concentration of 1 μM. Inhibits antidiuretic effect of Ang-(1-7) in water-loaded rats. Also attenuates Monocrotaline-induced pulmonary fibrosis in rats.

Technical Data for A 779

M. Wt	872.98
Formula	C₃₉H₆₀N₁₂O₁₁
Single Letter Sequence	DRVYIHA (Modifications: Ala-7 = D-Ala)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	159432-28-7
PubChem ID	10169886
InChi Key	GZSZZUXDAPDPOR-NGIFJXEWSA-N
Smiles	[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@H](C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 779

Solubility

Soluble to 1mg/ml in water

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for A 779

References are publications that support the biological activity of the product.

Becker Cardiovascular effects of angiotensin II and angiotensin-(1-7) at the RVLM of trained normotensive rats. Brain Res. 2005 PMID: 15804433
Santos Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors. Brain Res.Bull. 1994 PMID: 7850477
Bruce Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis. Br.J.Pharmacol. 2015 PMID: 25522140