Key Product Details
Description: | Potent and selective P2X7 antagonist |
Chemical Name: | N-[1-[[(Cyanoamino)(5-quinolinylamino)methylene]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 474.55 |
Customers also Viewed
Customers also Purchased
Citations for A 740003 (13)
Citations are publications that use Bio-Techne products. Selected citations for A 740003 include:
-
De Marchi et al.
(2019)
The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment.
Oncogene.
2019;
PMID: 30655604 -
Zumerle et al.
(2019)
Intercellular Calcium Signaling Induced by ATP Potentiates Macrophage Phagocytosis.
Cell Rep.
27:1
PMID: 30943393 -
Bergamin et al.
(2019)
Role of the P2X7 receptor in in vitro and in vivo glioma tumor growth.
Oncotarget.
10:4840
PMID: 31448051 -
Gilbert et al.
(2019)
ATP in the tumour microenvironment drives expression of nfP2X7, a key mediator of cancer cell survival.
Oncogene.
38:194
PMID: 30087439 -
Agrawal et al.
(2016)
P2X7Rs are involved in cell death, growth and cellular signaling in primary human osteoblasts
Bone.
95:91
PMID: 27856358 -
Englezou et al.
(2015)
P2X7R activation drives distinct IL-1 responses in dendritic cells compared to macrophages.
Cytokine.
74:293
PMID: 26068648 -
Adamczyk et al.
(2015)
P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2.
J.Cell Sci..
128:4615
PMID: 26542019 -
Song et al.
(2015)
Up-regulation of P2X7 receptors mediating proliferation of Schwann cells after sciatic nerve injury.
J Cell Sci.
11:203
PMID: 25682129 -
Adamczyk et al.
(2015)
P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2.
Br J Pharmacol.
128:4615
PMID: 26542019 -
Ashpole et al.
(2013)
Loss of calcium/calmodulin-dependent protein kinase II activity in cortical astrocytes decreases glutamate uptake and induces neurotoxic release of ATP.
J Biol Chem.
288:14599
PMID: 23543737 -
Hazleton et al.
(2012)
Purinergic receptors are required for HIV-1 infection of primary human macrophages.
J Immunol.
188:4488
PMID: 22450808 -
Amoroso et al.
(2012)
The P2X7 receptor is a key modulator of aerobic glycolysis.
Cell Death Dis.
3:e370
PMID: 22898868 -
Grol et al.
(2012)
P2X?-mediated calcium influx triggers a sustained, PI3K-dependent increase in metabolic acid production by osteoblast-like cells.
Am J Physiol Endocrinol Metab.
302:E561
PMID: 22185840
There are no citations that match your criteria.