A-71623

Catalog # 2411 | Tocris Bioscience a Bio-Techne Brand

Potent and selective CCK1 agonist; suppresses feeding

Key Product Details

Description:	Potent and selective CCK₁ agonist; suppresses feeding
Purity:	≥95% (HPLC)
Molecular Weight:	840.97

View Full Technical Details for A-71623

Technical Data
Citations / Reviews

Biological Activity for A-71623

A-71623 is a potent CCK₁ agonist (IC₅₀ = 3.7 nM) with 1200-fold selectivity over the CCK₂ receptor. Suppresses food intake following central or peripheral administration.

Technical Data for A-71623

M. Wt	840.97
Formula	C₄₄H₅₆N₈O₉
Single Letter Sequence	WKDF (Modifications: Trp-1 = Boc-Trp, Lys-2 = Lys(Tac), Phe-4 = N-methyl-Phe & C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	130408-77-4
PubChem ID	121964
InChi Key	KNHCBYMGWWTGSO-ZYADHFCISA-N
Smiles	O=C(N[C@H]([C@](N[C@@H](CC(O)=O)C(N(C)[C@@H](CC3=CC=CC=C3)C(N)=O)=O)=O)CCCCNC(NC4=CC=CC=C4C)=O)[C@@H](NC(OC(C)(C)C)=O)CC1=CNC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A-71623

Solubility

Soluble to 1mg/ml in 20mM PBS buffer

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References for A-71623

References are publications that support the biological activity of the product.

Asin A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey. Pharmacol.Biochem.Behav. 1992 PMID: 1513850
DeNinno Development of CCK-tetrapeptide analogues as potent and selective CCK-A receptor agonists. J.Med.Chem.
Lin Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. Mol.Pharmacol.

Citations for A-71623

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