A 484954

Name: A 484954
Brand: Tocris Bioscience
SKU: 4483

Tocris Bioscience, part of Bio-Techne | Catalog # 4483

Citations (5)

COA / SDS

CaM kinase III (eEF-2 kinase) inhibitor

Key Product Details

Description:	CaM kinase III (eEF-2 kinase) inhibitor
Chemical Name:	7-Amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidine-6-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	289.29

View Full Technical Details for A 484954

Technical Data
Citations

Biological Activity for A 484954

A 484954 is an inhibitor of eukaryotic elongation factor-2 (eEF-2) kinase (IC₅₀ = 0.28 μM in enzymatic assay). Reduces eEF-2 phosphorylation with little effect on cancer cell growth.

Technical Data for A 484954

M. Wt	289.29
Formula	C₁₃H₁₅N₅O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	142557-61-7
PubChem ID	14998470
InChi Key	HWODCHXORCTEGU-UHFFFAOYSA-N
Smiles	O=C(N(C3CC3)C2=C1C=C(C(N)=O)C(N)=N2)N(CC)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 484954

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	2.89	10

Preparing Stock Solutions for A 484954

The following data is based on the product molecular weight 289.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	34.57 mL	172.84 mL	345.67 mL
0.5 mM	6.91 mL	34.57 mL	69.13 mL
1 mM	3.46 mL	17.28 mL	34.57 mL
5 mM	0.69 mL	3.46 mL	6.91 mL

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References for A 484954

References are publications that support the biological activity of the product.

Chen 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J.Biol.Chem. 2011 PMID: 22020937