A 484954
Tocris Bioscience, part of Bio-Techne | Catalog # 4483
CaM kinase III (eEF-2 kinase) inhibitor
Key Product Details
Description
CaM kinase III (eEF-2 kinase) inhibitor
Product Description
A 484954 is an inhibitor of eukaryotic elongation factor-2 (eEF-2) kinase (IC50 = 0.28 μM in enzymatic assay). Reduces eEF-2 phosphorylation with little effect on cancer cell growth.Product Specifications
Molecular Weight
289.29
Formula
C13H15N5O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
7-Amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidine-6-carboxamide
CAS Number
142557-61-7
PubChem ID
14998470
InChI Key
HWODCHXORCTEGU-UHFFFAOYSA-N
SMILES
O=C(N(C3CC3)C2=C1C=C(C(N)=O)C(N)=N2)N(CC)C1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.89 | 10 |
Preparing Stock Solutions
for A 484954
The following data is based on the product molecular weight 289.29
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 34.57 mL | 172.84 mL | 345.67 mL |
| 0.5 mM | 6.91 mL | 34.57 mL | 69.13 mL |
| 1 mM | 3.46 mL | 17.28 mL | 34.57 mL |
| 5 mM | 0.69 mL | 3.46 mL | 6.91 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for A 484954
For research use only
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