A 425619

Tocris Bioscience, part of Bio-Techne | Catalog # 5781

Potent TRPV1 antagonist
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Key Product Details

Description

Potent TRPV1 antagonist

View all TRPV Antagonists »

Product Description

A 425619 is a potent TRPV1 antagonist (IC50 = 3-9 nM). Blocks capsaicin-evoked currents in rat DRG neurons and inhibits TRPV1-activation by anandamide (Cat. No. 1339) and N-arachidonoyl-dopamine. Reduces pain in inflammatory, postoperative and osteoarthritic in vivo pain models.

Product Specifications

Molecular Weight

345.32

Formula

C18H14F3N3O

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

N-5-Isoquinolinyl-N'-[[(4-(trifluoromethyl)phenyl]methyl]urea

CAS Number

581809-67-8

PubChem ID

8068410

InChI Key

SJGVXVZUSQLLJB-UHFFFAOYSA-N

SMILES

O=C(NCC1=CC=C(C(F)(F)F)C=C1)NC2=CC=CC3=CN=CC=C32

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.53 100
Ethanol 34.53 100

Preparing Stock Solutions for A 425619

The following data is based on the product molecular weight 345.32

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.90 mL 14.48 mL 28.96 mL
5 mM 0.58 mL 2.90 mL 5.79 mL
10 mM 0.29 mL 1.45 mL 2.90 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Product Documents for A 425619

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for A 425619

For research use only

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