A 286982

Name: A 286982
Brand: Tocris Bioscience
SKU: 4228
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 4228

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Key Product Details

Description:	Potent inhibitor of the LFA-1/ICAM-1 interaction
Chemical Name:	(2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one
Purity:	≥99% (HPLC)
Molecular Weight:	453.55

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Biological Activity for A 286982

A 286982 is a potent inhibitor of the LFA-1/ICAM-1 interaction (IC₅₀ values are 44 and 35 nM in LFA-1/ICAM-1 binding and LFA-1-mediated cell adhesion assays respectively).

Compound Libraries for A 286982

A 286982 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for A 286982

M. Wt	453.55
Formula	C₂₄H₂₇N₃O₄S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	280749-17-9
PubChem ID	9846729
InChi Key	HTGGAYLWTDOFDK-PKNBQFBNSA-N
Smiles	O=C(C)N1CCN(C(/C=C/C2=CC([N+]([O-])=O)=C(SC3=CC=CC=C3C(C)C)C=C2)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 286982

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	45.35	100
	ethanol	22.68	50

Preparing Stock Solutions for A 286982

The following data is based on the product molecular weight 453.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.20 mL	11.02 mL	22.05 mL
5 mM	0.44 mL	2.20 mL	4.41 mL
10 mM	0.22 mL	1.10 mL	2.20 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for A 286982

References are publications that support the biological activity of the product.

Liu Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. Identification of an additional binding pocket based on an anilino diaryl sulfide lead. J.Med.Chem. 2000 PMID: 11052808

Citations for A 286982

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A 286982 was used to inhibit the action of LFA-1 ( alpha L beta 2) and measure effects

Name: Anonymous

Species: Human

alpha L beta 2 is crucial for lymphocyte adhesion and costimulation. We worked to determine alpha L beta 2's role in leukocyte adhesion to and migration through endothelium by its ability to bind intercellular adhesion molecules (ICAMs). A 286982 was used to inhibit the action and measure effects.

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Product Documents for A 286982

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.