8-Bromo-cGMP, sodium salt

Name: 8-Bromo-cGMP, sodium salt
Brand: Tocris Bioscience
SKU: 1089

Catalog # 1089

Citations (3)

COA / SDS

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Key Product Details

Description:	cGMP analog; activates PKG
Chemical Name:	8-Bromoguanosine cyclic 3',5'-monophosphate sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	446.09

View Full Technical Details for 8-Bromo-cGMP, sodium salt

Biological Activity

8-Bromo-cGMP, sodium salt is a membrane permeable cGMP analog that activates protein kinase G (PKG). 4.3-fold more potent than cGMP in activating PKG1α and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro.

Technical Data

M. Wt	446.09
Formula	C₁₀H₁₀BrN₅NaO₇P
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	51116-01-9
PubChem ID	23702959
InChi Key	ZJRFCXHKYQVNFK-YEOHUATISA-M
Smiles	[Na+].[H][C@@]12COP([O-])(=O)O[C@@]1([H])[C@@H](O)[C@@H](O2)N1C(Br)=NC2=C1NC(N)=NC2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	44.61	100

Preparing Stock Solutions

The following data is based on the product molecular weight 446.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.21 mL	22.42 mL
5 mM	0.45 mL	2.24 mL	4.48 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Sekhar Relaxation of pig coronary arteries by new and potent cGMP analogs that selectively activate type 1α, compared with type 1β, cGMP-dependent protein kinase. Mol.Pharmacol. 1992 PMID: 1321950
Buchan Modulation of agonist-induced calcium mobilisation in bovine aortic endothelial cells by phorbol myristate acetate and cyclic AMP but not cyclic GMP. Br.J.Pharmacol. 1991 PMID: 1665733
Ignarro Stimulation of phagocytic release of neutral protease from human neutrophils by cholinergic amines and cyclic 3',5'-guanosine monophosphate. J.Immunol. 1974 PMID: 4359834

Citations for 8-Bromo-cGMP, sodium salt (3)

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Citations are publications that use Bio-Techne products. Selected citations for 8-Bromo-cGMP, sodium salt include:

Foster et al. (2014) Nitric oxide-mediated modulation of the murine locomotor network. J Neurophysiol. 111:659
PMID: 24259545
Huang and Hsu (2010) Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex. 20:982
PMID: 19666830
Capuano et al. (2009) Proinflammatory-activated trigeminal satellite cells promote neuronal sensitization: relevance for migraine pathology. Mol Pain. 5:43
PMID: 19660121

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