8-Bromo-cGMP, sodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 1089
cGMP analog; activates PKG
Key Product Details
Description
cGMP analog; activates PKG
Product Description
8-Bromo-cGMP, sodium salt is a membrane permeable cGMP analog that activates protein kinase G (PKG). 4.3-fold more potent than cGMP in activating PKG1α and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro.Product Specifications
Molecular Weight
446.09
Formula
C10H10BrN5NaO7P
Storage
Desiccate at -20°C
Purity
≥98% (HPLC)
Chemical Name
8-Bromoguanosine cyclic 3',5'-monophosphate sodium salt
CAS Number
51116-01-9
PubChem ID
23702959
InChI Key
ZJRFCXHKYQVNFK-YEOHUATISA-M
SMILES
[Na+].[H][C@@]12COP([O-])(=O)O[C@@]1([H])[C@@H](O)[C@@H](O2)N1C(Br)=NC2=C1NC(N)=NC2=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 44.61 | 100 |
Preparing Stock Solutions
for 8-Bromo-cGMP, sodium salt
The following data is based on the product molecular weight 446.09
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.24 mL | 11.21 mL | 22.42 mL |
| 5 mM | 0.45 mL | 2.24 mL | 4.48 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.24 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ignarro Stimulation of phagocytic release of neutral protease from human neutrophils by cholinergic amines and cyclic 3',5'-guanosine monophosphate. J.Immunol. 1974 PMID: 4359834
- Sekhar Relaxation of pig coronary arteries by new and potent cGMP analogs that selectively activate type 1α, compared with type 1β, cGMP-dependent protein kinase. Mol.Pharmacol. 1992 PMID: 1321950
- Buchan Modulation of agonist-induced calcium mobilisation in bovine aortic endothelial cells by phorbol myristate acetate and cyclic AMP but not cyclic GMP. Br.J.Pharmacol. 1991 PMID: 1665733
Product Specific Notices for 8-Bromo-cGMP, sodium salt
For research use only
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