680C91

Tocris Bioscience, part of Bio-Techne | Catalog # 4392

Potent and selective tryptophan 2,3-dioxygenase (TDO) inhibitor
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Key Product Details

Description

Potent and selective tryptophan 2,3-dioxygenase (TDO) inhibitor

View all Tryptophan 2,3 Dioxygenase Inhibitors »

Product Description

680C91 is a potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) (Ki = 51 nM). Exhibits no activity against indoleamine 2,3-dioxygenase, monoamine oxidase A and B, 5-HT uptake or 5-HT1A, 1D, 2A and 2C receptors. Produces large increases in brain tryptophan and serotonin in vitro and in vivo in the rat.

Product Specifications

Molecular Weight

238.26

Formula

C15H11FN2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-1H-indole

CAS Number

163239-22-3

PubChem ID

10014426

InChI Key

YBSDQTBCNYWBMX-ONEGZZNKSA-N

SMILES

FC1=CC=C2C(NC=C2/C=C/C3=CN=CC=C3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.83 100
Ethanol 11.91 50

Preparing Stock Solutions for 680C91

The following data is based on the product molecular weight 238.26

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.20 mL 20.99 mL 41.97 mL
5 mM 0.84 mL 4.20 mL 8.39 mL
10 mM 0.42 mL 2.10 mL 4.20 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for 680C91

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 680C91

For research use only

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