(5Z)-7-Oxozeaenol

Product Description

(5Z)-7-Oxozeaenol is a resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor-β-activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC₅₀ = 8 nM). Displays > 33-fold and > 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF-κB (IC₅₀ = 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF-α-induced apoptosis in vitro.

Solubility

Preparing Stock Solutions for (5Z)-7-Oxozeaenol

The following data is based on the product molecular weight 362.37

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	11.04 mL	55.19 mL	110.38 mL
1.25 mM	2.21 mL	11.04 mL	22.08 mL
2.5 mM	1.10 mL	5.52 mL	11.04 mL
12.5 mM	0.22 mL	1.10 mL	2.21 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Choo Blockade of transforming growth factor-β-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade. Mol.Cancer Ther. 2006 PMID: 17172402
• Windheim Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide. Biochem.J. 2007 PMID: 17348859
• Ninomiya-Tsuji A resorcyclic acid lactone, 5Z-7-Oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. J.Biol.Chem. 2003 PMID: 12624112