5-Iodotubercidin

Product Description

5-Iodotubercidin is a potent adenosine kinase inhibitor (IC₅₀ = 26 nM). Also nucleoside transporter inhibitor (IC₅₀ values are < 25 nM, 7 μM and 15 μM for inhibition of [³H]adenosine, [³H]uridine and [³H]formycin B uptake respectively). Strongly stimulates glycogen synthesis in hepatocytes via activation of glycogen synthase. Also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC (IC₅₀ values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 μM respectively). Decreases hippocampal DNA methylation through adenosine kinase inhibition in vivo.

Solubility

Preparing Stock Solutions for 5-Iodotubercidin

The following data is based on the product molecular weight 392.15

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.10 mL	25.50 mL	51.00 mL
2.5 mM	1.02 mL	5.10 mL	10.20 mL
5 mM	0.51 mL	2.55 mL	5.10 mL
25 mM	0.10 mL	0.51 mL	1.02 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Williams-Karnesky Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis. J.Clin.Invest. 2013 PMID: 23863710
• Parkinson and Geiger Effects of iodotubercidin on adenosine kinase activity and nucleoside transport in DDT₁ MF-2 smooth muscle cells. J.Pharmacol.Exp.Ther. 1996 PMID: 8667202
• Ugarkar Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues. J.Med.Chem. 2000 PMID: 10956196
• Massillon Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor. Biochem.J. 1994 PMID: 8166629