4μ8C
Tocris Bioscience, part of Bio-Techne | Catalog # 4479
Inhibits IRE1α endoribonuclease activity
Product Description
4μ8C is a selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Blocks substrate access to the active site of IRE1α. Inactivates IRE1α-mediated mRNA degradation. Displays no effect on the IRE1α-related endoribonuclease RNase L.Product Specifications
Molecular Weight
204.18
Formula
C11H8O4
Storage
Store at -20°C
Purity
≥98%
Chemical Name
7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde
CAS Number
14003-96-4
PubChem ID
12934390
InChI Key
RTHHSXOVIJWFQP-UHFFFAOYSA-N
SMILES
CC(C1=CC=C(O)C(C=O)=C1O2)=CC2=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.42 | 100 |
Preparing Stock Solutions
for 4μ8C
The following data is based on the product molecular weight 204.18
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.90 mL | 24.49 mL | 48.98 mL |
| 5 mM | 0.98 mL | 4.90 mL | 9.80 mL |
| 10 mM | 0.49 mL | 2.45 mL | 4.90 mL |
| 50 mM | 0.10 mL | 0.49 mL | 0.98 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cross The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc.Natl.Acad.Sci.USA 2012 PMID: 22315414
Product Specific Notices for 4μ8C
For research use only
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