4EGI-1

Name: 4EGI-1
Brand: Tocris Bioscience
SKU: 4800
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4800

(1)

Citations (30)

COA / SDS

Inhibits eIF4E:eIF4G subunit interaction

Key Product Details

Description:	Inhibits eIF4E:eIF4G subunit interaction
Chemical Name:	α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	451.28

View Full Technical Details for 4EGI-1

Technical Data
Citations / Reviews (1)

Biological Activity for 4EGI-1

4EGI-1 is an inhibitor of eIF4E:eIF4G interaction; prevents eIF4E binding to eIF4G. Binds eIF4E and inhibits cap-dependent translation but not initiation factor-independent translation. Exhibits activity against Jurkat and A549 cells.

Technical Data for 4EGI-1

M. Wt	451.28
Formula	C₁₈H₁₂Cl₂N₄O₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	315706-13-9
PubChem ID	6911989
InChi Key	KFRKRECSIYXARE-HMAPJEAMSA-N
Smiles	OC(=O)C(\CC1=CC=CC=C1[N+]([O-])=O)=N/NC1=NC(=CS1)C1=CC(Cl)=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 4EGI-1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	45.13	100

Preparing Stock Solutions for 4EGI-1

The following data is based on the product molecular weight 451.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.22 mL	11.08 mL	22.16 mL
5 mM	0.44 mL	2.22 mL	4.43 mL
10 mM	0.22 mL	1.11 mL	2.22 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for 4EGI-1

References are publications that support the biological activity of the product.

Moerke Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell 2007 PMID: 17254965
Gkogkas Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature 2013 PMID: 23172145