4EGI-1

Tocris Bioscience, part of Bio-Techne | Catalog # 4800

Inhibits eIF4E:eIF4G subunit interaction
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Key Product Details

Description

Inhibits eIF4E:eIF4G subunit interaction

View all Protein-synthesizing GTPase Compounds »

Product Description

4EGI-1 is an inhibitor of eIF4E:eIF4G interaction; prevents eIF4E binding to eIF4G. Binds eIF4E and inhibits cap-dependent translation but not initiation factor-independent translation. Exhibits activity against Jurkat and A549 cells.

Product Specifications

Molecular Weight

451.28

Formula

C18H12Cl2N4O4S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid

CAS Number

315706-13-9

PubChem ID

6911989

InChI Key

KFRKRECSIYXARE-HMAPJEAMSA-N

SMILES

OC(=O)C(\CC1=CC=CC=C1[N+]([O-])=O)=N/NC1=NC(=CS1)C1=CC(Cl)=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.13 100

Preparing Stock Solutions for 4EGI-1

The following data is based on the product molecular weight 451.28

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.08 mL 22.16 mL
5 mM 0.44 mL 2.22 mL 4.43 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for 4EGI-1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 4EGI-1

For research use only

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