4-P-PDOT

Name: 4-P-PDOT
Brand: Tocris Bioscience
SKU: 1034

Tocris Bioscience a Bio-Techne Brand

Catalog # 1034

Citations (8)

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Key Product Details

Description:	MT₂ antagonist
Alternative Names:	AH 024
Chemical Name:	cis-4-Phenyl-2-propionamidotetralin
Purity:	≥99% (HPLC)
Molecular Weight:	279.38

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Biological Activity for 4-P-PDOT

4-P-PDOT is a melatonin receptor antagonist, >300-fold selective for the MT₂ (vs MT₁) subtype.

Compound Libraries for 4-P-PDOT

4-P-PDOT is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for 4-P-PDOT

M. Wt	279.38
Formula	C₁₉H₂₁NO
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	620170-78-7
PubChem ID	3976006
InChi Key	RCYLUNPFECYGDW-UHFFFAOYSA-N
Smiles	CCC(=O)NC1CC(C2=CC=CC=C2)C2=C(C1)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 4-P-PDOT

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.94	100
	ethanol	27.94	100

Preparing Stock Solutions for 4-P-PDOT

The following data is based on the product molecular weight 279.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.58 mL	17.90 mL	35.79 mL
5 mM	0.72 mL	3.58 mL	7.16 mL
10 mM	0.36 mL	1.79 mL	3.58 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

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References for 4-P-PDOT

References are publications that support the biological activity of the product.

Dubocovich Melatonin receptor antagonists that differentiate between the human Mel_1a and Mel_1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina M_L1 presynaptic heteroceptor. Naunyn Schmiedebergs Arch.Pharmacol. 1997 PMID: 9089668
Dubocovich Melatonin receptors: are there multiple subtypes? TiPS 1995 PMID: 7762083

Citations for 4-P-PDOT (8)

Showing 1 - 8 of 8 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for 4-P-PDOT include:

Hou et al. (2017) Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats. Front Cell Neurosci. 11:98
PMID: 28473754
Chen et al. (2014) Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain. J Clin Invest. 20:1298
PMID: 24574803
Faria et al. (2013) Melatonin acts through MT1/MT2 receptors to activate hypothalamic Akt and suppress hepatic gluconeogenesis in rats. Am J Physiol Endocrinol Metab. 305:E230
PMID: 23695212
Tunstall et al. (2011) MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. J Pharmacol Exp Ther. 336:127
PMID: 20959363
Jones et al. (2010) Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol. 80:1478
PMID: 20696141
Zhao et al. (2010) Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells. J Physiol. 588:2605
PMID: 20519319
Danilova et al. (2004) Melatonin stimulates cell proliferation in zebrafish embryo and accelerates its development. J Pharmacol Exp Ther. 18:751
PMID: 14766799
Sjöblom et al. (2001) Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. FASEB J. 108:625
PMID: 11518737

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