4-Methylhistamine dihydrochloride

Name: 4-Methylhistamine dihydrochloride
Brand: Tocris Bioscience
SKU: 2342

Catalog # 2342 | Tocris Bioscience a Bio-Techne Brand

Citations (4)

COA / SDS

Selective, high affinity H4 agonist

Key Product Details

Description:	Selective, high affinity H₄ agonist
Chemical Name:	5-(2-Aminoethyl)-4-methylimidazole dihydrochloride
Molecular Weight:	198.09

View Full Technical Details for 4-Methylhistamine dihydrochloride

Technical Data
Citations (4) / Reviews

Biological Activity for 4-Methylhistamine dihydrochloride

4-Methylhistamine dihydrochloride is a potent, high affinity H₄ receptor agonist (K_i = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.

Technical Data for 4-Methylhistamine dihydrochloride

M. Wt	198.09
Formula	C₆H₁₁N₃.2HCl
Storage	Desiccate at RT
CAS Number	36376-47-3
PubChem ID	215819
InChi Key	BVJIXYJOFWYOBL-UHFFFAOYSA-N
Smiles	Cl.Cl.CC1=C(CCN)NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 4-Methylhistamine dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	246.8	50

Preparing Stock Solutions for 4-Methylhistamine dihydrochloride

The following data is based on the product molecular weight 198.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	10.10 mL	50.48 mL	100.96 mL
2.5 mM	2.02 mL	10.10 mL	20.19 mL
5 mM	1.01 mL	5.05 mL	10.10 mL
25 mM	0.20 mL	1.01 mL	2.02 mL

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References for 4-Methylhistamine dihydrochloride

References are publications that support the biological activity of the product.

Gbahou Compared pharmacology of human histamine H₃ and H₄ receptors: structure-activity relationships of histamine derivatives. Br.J.Pharmacol
Lim Evaluation of histamine H₁-, H₂-, and H₃-receptor ligands at the human histamine H₄ receptor: identification of 4-methylhistamine as the first potent and selective H₄ receptor agonist. J.Pharmacol.Exp.Ther. 2005 PMID: 15947036

Citations for 4-Methylhistamine dihydrochloride (4)

Showing 1 - 4 of 4 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for 4-Methylhistamine dihydrochloride include:

Kim et al. (2013) Effects of histamine on cultured interstitial cells of cajal in murine small intestine. Korean J Physiol Pharmacol. 17:149
PMID: 23626477
Desmadryl et al. (2012) Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability. Br J Pharmacol. 167:905
PMID: 22624822
Connelly et al. (2009) The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS. Br J Pharmacol. 157:55
PMID: 19413571
Holden et al. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. Bone Joint Res. 152:891
PMID: 17891168

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