4-Methylhistamine dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2342
Selective, high affinity H4 agonist
Key Product Details
Description
Selective, high affinity H4 agonist
Product Description
4-Methylhistamine dihydrochloride is a potent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.Product Specifications
Molecular Weight
198.09
Formula
C6H11N3.2HCl
Storage
Desiccate at RT
Chemical Name
5-(2-Aminoethyl)-4-methylimidazole dihydrochloride
CAS Number
36376-47-3
PubChem ID
215819
InChI Key
BVJIXYJOFWYOBL-UHFFFAOYSA-N
SMILES
Cl.Cl.CC1=C(CCN)NC=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 246.8 | 50 |
Preparing Stock Solutions
for 4-Methylhistamine dihydrochloride
The following data is based on the product molecular weight 198.09
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 10.10 mL | 50.48 mL | 100.96 mL |
| 2.5 mM | 2.02 mL | 10.10 mL | 20.19 mL |
| 5 mM | 1.01 mL | 5.05 mL | 10.10 mL |
| 25 mM | 0.20 mL | 1.01 mL | 2.02 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gbahou Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives. Br.J.Pharmacol
- Lim Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J.Pharmacol.Exp.Ther. 2005 PMID: 15947036
Product Specific Notices for 4-Methylhistamine dihydrochloride
For research use only
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