4-HQN

Name: 4-HQN
Brand: Tocris Bioscience
SKU: 2192

Tocris Bioscience, part of Bio-Techne | Catalog # 2192

COA / SDS

PARP inhibitor

Discontinued Product

2192 has been discontinued. View all Poly(ADP-ribose) Polymerase Inhibitors products.

Key Product Details

Description:	PARP inhibitor
Chemical Name:	4-(1H)-Quinazolinone
Purity:	≥99% (HPLC)
Molecular Weight:	146.15

View Full Technical Details for 4-HQN

Technical Data
Citations

Biological Activity for 4-HQN

Inhibitor of poly(ADP-ribose) polymerase (PARP) (IC₅₀= 9.5 μM); displays mixed inhibition with respect to NAD⁺. Protective against ischemia-reperfusion induced ROS production, and subsequent mitochondrial and cell damage in rat heart. Anti-inflammatory in LPS-induced endotoxic mice in vivo; decreases NF-κB and AP-1 activation.

Technical Data for 4-HQN

M. Wt	146.15
Formula	C₈H₆N₂O
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	491-36-1
PubChem ID	63112
InChi Key	QMNUDYFKZYBWQX-UHFFFAOYSA-N
Smiles	OC1=C2C=CC=CC2=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for 4-HQN

References are publications that support the biological activity of the product.

Halmosi Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system. Mol.Pharmacol. 2001 PMID: 11353811
Veres Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice. J.Pharmacol.Exp.Ther. 2004 PMID: 14999056
Banasik Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase. J.Biol.Chem. 1992 PMID: 1530940

4-HQN

Tocris Bioscience, part of Bio-Techne | Catalog # 2192

Key Product Details

Biological Activity for 4-HQN

Technical Data for 4-HQN

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for 4-HQN

Product Documents for 4-HQN

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

Stay Connected