4-CMTB

Tocris Bioscience, part of Bio-Techne | Catalog # 4642

COA / SDS

FFA2 agonist; also exhibits positive allosteric modulatory activity

Key Product Details

Description:	FFA2 agonist; also exhibits positive allosteric modulatory activity
Chemical Name:	4-chloro-α-(1-methylethyl)-N-2-thiazolylbenzeneacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	294.8

View Full Technical Details for 4-CMTB

Technical Data
Citations

Biological Activity for 4-CMTB

4-CMTB is a free fatty acid receptor FFA2 agonist (pEC₅₀ = 6.38) and positive allosteric modulator. Binds at a site distinct from the orthosteric site; modulates the activity of short-chain fatty acids at FFA2 via the FFA2 second extracellular loop (ECL2).

Compound Libraries for 4-CMTB

4-CMTB is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for 4-CMTB

M. Wt	294.8
Formula	C₁₄H₁₅ClN₂OS
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	300851-67-6
PubChem ID	4307629
InChi Key	AZYDQCGCBQYFSE-UHFFFAOYSA-N
Smiles	ClC1=CC=C(C(C(C)C)C(NC2=NC=CS2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 4-CMTB

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	29.48	100
	ethanol	5.9	20

Preparing Stock Solutions for 4-CMTB

The following data is based on the product molecular weight 294.8.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.39 mL	16.96 mL	33.92 mL
5 mM	0.68 mL	3.39 mL	6.78 mL
10 mM	0.34 mL	1.70 mL	3.39 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

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Reconstitution Calculator

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References for 4-CMTB

References are publications that support the biological activity of the product.

Milligan Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3. Br.J.Pharmacol. 2009 PMID: 19719777
Smith Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Mol.Pharmacol. 2011 PMID: 21498659