4-Chlorophenylguanidine hydrochloride

Name: 4-Chlorophenylguanidine hydrochloride
Brand: Tocris Bioscience
SKU: 0442

Catalog # 0442

Citations (1)

COA / SDS

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Key Product Details

Description:	Urokinase inhibitor
Purity:	≥98% (HPLC)
Molecular Weight:	206.07

View Full Technical Details for 4-Chlorophenylguanidine hydrochloride

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Biological Activity

4-Chlorophenylguanidine hydrochloride is a potent and specific inhibitor of urokinase. Also a positive allosteric modulator at acid sensing ion channel 3 (ASIC3), which increases its pH sensitivity.

Technical Data

M. Wt	206.07
Formula	C₇H₈ClN₃.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	14279-91-5
PubChem ID	44134626
InChi Key	RMFZXBDENVVLSL-UHFFFAOYSA-N
Smiles	Cl.NC(=N)NC1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions

The following data is based on the product molecular weight 206.07.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.85 mL	24.26 mL	48.53 mL
5 mM	0.97 mL	4.85 mL	9.71 mL
10 mM	0.49 mL	2.43 mL	4.85 mL
50 mM	0.10 mL	0.49 mL	0.97 mL

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References

References are publications that support the biological activity of the product.

Agharkar & Gonzales 4-Chlorophenylguanidine is an ASIC3 agonist and positive allosteric modulator. J.Pharmacol.Sci. 2017 PMID: 28259560
Yang Selective inhibition of urok. by substituted phenylguanidines: quantitative structure-activity relationship analyses. J.Med.Chem. 1990 PMID: 2231595

Citations for 4-Chlorophenylguanidine hydrochloride (1)

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Citations are publications that use Bio-Techne products. Selected citations for 4-Chlorophenylguanidine hydrochloride include:

Agharkar & Gonzales 4-Chlorophenylguanidine is an ASIC3 agonist and positive allosteric modulator. J.Pharmacol.Sci.. 133:184
PMID: 28259560

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