4-Chlorophenylguanidine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0442
Urokinase inhibitor; also positive allosteric modulator at ASIC3
Key Product Details
Description
Urokinase inhibitor; also positive allosteric modulator at ASIC3
Product Description
4-Chlorophenylguanidine hydrochloride is a potent inhibitor of urokinase. Also a positive allosteric modulator at acid sensing ion channel 3 (ASIC3), which increases its pH sensitivity.Product Specifications
Molecular Weight
206.07
Formula
C7H8ClN3.HCl
Storage
Store at RT
Purity
≥98% (HPLC)
CAS Number
14279-91-5
PubChem ID
44134626
InChI Key
RMFZXBDENVVLSL-UHFFFAOYSA-N
SMILES
Cl.NC(=N)NC1=CC=C(Cl)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 |
Preparing Stock Solutions
for 4-Chlorophenylguanidine hydrochloride
The following data is based on the product molecular weight 206.07
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.85 mL | 24.26 mL | 48.53 mL |
| 5 mM | 0.97 mL | 4.85 mL | 9.71 mL |
| 10 mM | 0.49 mL | 2.43 mL | 4.85 mL |
| 50 mM | 0.10 mL | 0.49 mL | 0.97 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Agharkar & Gonzales 4-Chlorophenylguanidine is an ASIC3 agonist and positive allosteric modulator. J.Pharmacol.Sci. 2017 PMID: 28259560
- Yang Selective inhibition of urok. by substituted phenylguanidines: quantitative structure-activity relationship analyses. J.Med.Chem. 1990 PMID: 2231595
Product Specific Notices for 4-Chlorophenylguanidine hydrochloride
For research use only
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