4,9-Anhydrotetrodotoxin

Name: 4,9-Anhydrotetrodotoxin
Brand: Tocris Bioscience
SKU: 6159

Tocris Bioscience, part of Bio-Techne | Catalog # 6159

Citations (17)

COA / SDS

Potent and selective Nav1.6 channel blocker

Discontinued Product

6159 has been discontinued. View all Voltage-gated Sodium Channel Blockers products.

Key Product Details

Description:	Potent and selective Na_v1.6 channel blocker
Alternative Names:	4,9-anhydro-TTX
Chemical Name:	(4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-Amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol
Purity:	≥98% (HPLC)
Molecular Weight:	301.25

View Full Technical Details for 4,9-Anhydrotetrodotoxin

Technical Data
Citations

Biological Activity for 4,9-Anhydrotetrodotoxin

4,9-Anhydrotetrodotoxin is a potent and selective Na_v1.6 channel blocker (IC₅₀ values are 7.8, 341, 988, 1260, 1270, 78500 and >30000 nM for Na_v1.6, Na_v1.3, Na_v1.4, Na_v1.2, Na_v1.7, Na_v1.5 and Na_v1.8). Derivative of tetrodotoxin (Cat. No. 1078).

Technical Data for 4,9-Anhydrotetrodotoxin

M. Wt	301.25
Formula	C₁₁H₁₅N₃O₇
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	13072-89-4
PubChem ID	11243537
InChi Key	STNXQECXKDMLJK-PZKHIREQSA-N
Smiles	O[C@@]1(CO)[C@H](O2)[C@H]([C@H](O3)NC(N4[H])=N)[C@]54[C@H]3[C@@]2(O)O[C@H]1[C@H]5O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for 4,9-Anhydrotetrodotoxin

References are publications that support the biological activity of the product.

Hargus Evidence for a role of Na_v1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis J.Neurophysiol 2013 PMID: 23741036
Rosker The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Na_v1.6 voltage-dependent sodium channel. Am.J.Physiol.Cell Physiol. 2007 PMID: 17522141

4,9-Anhydrotetrodotoxin

Tocris Bioscience, part of Bio-Techne | Catalog # 6159

Key Product Details

Biological Activity for 4,9-Anhydrotetrodotoxin

Technical Data for 4,9-Anhydrotetrodotoxin

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for 4,9-Anhydrotetrodotoxin

Product Documents for 4,9-Anhydrotetrodotoxin

COA

Certificate of Analysis

SDS

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