4,9-Anhydrotetrodotoxin

Name: 4,9-Anhydrotetrodotoxin
Brand: Tocris Bioscience
SKU: 6159

Tocris Bioscience a Bio-Techne Brand

Catalog # 6159

Citations (1)

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	Potent and selective Na_v1.6 channel blocker
Alternative Names:	4,9-anhydro-TTX
Chemical Name:	(4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-Amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol
Purity:	≥98% (HPLC)
Molecular Weight:	301.25

View Full Technical Details for 4,9-Anhydrotetrodotoxin

Biological Activity for 4,9-Anhydrotetrodotoxin

4,9-Anhydrotetrodotoxin is a potent and selective Na_v1.6 channel blocker (IC₅₀ values are 7.8, 341, 988, 1260, 1270, 78500 and >30000 nM for Na_v1.6, Na_v1.3, Na_v1.4, Na_v1.2, Na_v1.7, Na_v1.5 and Na_v1.8). Derivative of tetrodotoxin (Cat. No. 1078).

Technical Data for 4,9-Anhydrotetrodotoxin

M. Wt	301.25
Formula	C₁₁H₁₅N₃O₇
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	13072-89-4
PubChem ID	11243537
InChi Key	STNXQECXKDMLJK-PZKHIREQSA-N
Smiles	O[C@@]1(CO)[C@H](O2)[C@H]([C@H](O3)NC(N4[H])=N)[C@]54[C@H]3[C@@]2(O)O[C@H]1[C@H]5O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 4,9-Anhydrotetrodotoxin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	1

Preparing Stock Solutions for 4,9-Anhydrotetrodotoxin

The following data is based on the product molecular weight 301.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.04 mM	82.99 mL	414.94 mL	829.88 mL
0.2 mM	16.60 mL	82.99 mL	165.98 mL
0.4 mM	8.30 mL	41.49 mL	82.99 mL
2 mM	1.66 mL	8.30 mL	16.60 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for 4,9-Anhydrotetrodotoxin

References are publications that support the biological activity of the product.

Hargus Evidence for a role of Na_v1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis J.Neurophysiol 2013 PMID: 23741036
Rosker The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Na_v1.6 voltage-dependent sodium channel. Am.J.Physiol.Cell Physiol. 2007 PMID: 17522141

Citations for 4,9-Anhydrotetrodotoxin (1)

Showing 1 - 1 of 1 citation Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for 4,9-Anhydrotetrodotoxin include:

Vysokov et al. (2019) The role of NaV channels in synaptic transmission after axotomy in a microfluidic culture platform. Sci Rep. 9:12915
PMID: 31501450

There are no citations that match your criteria.