3-Mercaptopicolinic acid hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 7577

Phospoenolpyruvate carboxykinase (PEPCK) inhibitor; inhibits gluconeogenesis
Discontinued Product
7577 has been discontinued. View all PCK1 products.

Key Product Details

Description

Phospoenolpyruvate carboxykinase (PEPCK) inhibitor; inhibits gluconeogenesis

View all PCK1 »

Product Description

3-Mercaptopicolinic acid hydrochloride is a phospoenolpyruvate carboxykinase (PEPCK) inhibitor (IC50 = 7.5 μM at hPEPCK). Inhibits glucose synthesis. In vitro, 3-Mercaptopicolinic acid reduces proliferation of Treg cells, induces myogenic differentiation of C2C12 cells, and reduces colony growth formation of MCF7 cells. Also sensitizes melanoma cells to Vemurafenib (Cat. No. 7309) via inhibition of cytoplasmic PEPCK.

Product Specifications

Molecular Weight

191.63

Formula

C6H5NO2S.HCl

Storage

Store at -20°C

Chemical Name

3-Mercapto-2-pyridinecarboxylic acid hydrochloride

CAS Number

320386-54-7

PubChem ID

24721311

InChI Key

DYGYEUUVNLEHJP-UHFFFAOYSA-N

SMILES

O=C(C1=NC=CC=C1S)O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 1.92 10
DMSO 3.83 20

Preparing Stock Solutions for 3-Mercaptopicolinic acid hydrochloride

The following data is based on the product molecular weight 191.63

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 26.09 mL 130.46 mL 260.92 mL
1 mM 5.22 mL 26.09 mL 52.18 mL
2 mM 2.61 mL 13.05 mL 26.09 mL
10 mM 0.52 mL 2.61 mL 5.22 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for 3-Mercaptopicolinic acid hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 3-Mercaptopicolinic acid hydrochloride

For research use only

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