2-Methylthioadenosine triphosphate tetrasodium salt

Name: 2-Methylthioadenosine triphosphate tetrasodium salt
Brand: Tocris Bioscience
SKU: 1062

Catalog # 1062

Citations (3)

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Key Product Details

Description:	Non-selective P2 agonist
Alternative Names:	2-Methylthio-ATP
Chemical Name:	2-Methylthioadenosine-5'-triphosphate tetrasodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	641.2

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Biological Activity

2-Methylthioadenosine triphosphate tetrasodium salt is a P2 purinoceptor agonist.

Technical Data

M. Wt	641.2
Formula	C₁₁H₁₄N₅Na₄O₁₃P₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	100020-57-3
PubChem ID	16218831
InChi Key	UEEFBRHXFDJPTA-KWIZKVQNSA-J
Smiles	NC1=C2C(N([C@@H]3O[C@H](COP(OP(OP([O-])([O-])=O)([O-])=O)([O-])=O)[C@@H](O)[C@H]3O)C=N2)=NC(SC)=N1.[Na+].[Na+].[Na+].[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

Soluble in water (supplied pre-dissolved at a concentration of 10mM)

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References

References are publications that support the biological activity of the product.

Khakh International Union of Pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits. Pharmacol.Rev. 2001 PMID: 11171941
McMurray Purinoceptor subtypes mediating contraction and relaxation of marmoset urinary bladder smooth muscle. Br.J.Pharmacol. 1998 PMID: 9605564
Burnstock Studies on the stereoselectivity of the P₂-purinoreceptor. Br.J.Pharmacol. 1983 PMID: 6317121
Cusack Specific but non-competitive inhibition by 2-alkylthioanalogues of adenosine 5'-monophosphate and adenosine 5'-triphosphate of human platelet aggregation induced by adenosine 5'-diphosphate. Br.J.Pharmacol. 1982 PMID: 7186826

Citations for 2-Methylthioadenosine triphosphate tetrasodium salt (3)

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Citations are publications that use Bio-Techne products. Selected citations for 2-Methylthioadenosine triphosphate tetrasodium salt include:

Nagai et al. (2017) Antihypertrophic Effects of Small Molecules that Maintain Mitochondrial ATP Levels Under Hypoxia. EBioMedicine. 24:147
PMID: 28942281
Rahbar et al. (2016) Purinergic and Cholinergic Drugs Mediate Hyperventilation in Zebrafish: Evidence from a Novel Chemical Screen. Nature. 11:e0154261
PMID: 27100625
Zhang et al. (2014) Agonist-bound structure of the human P2Y12 receptor. Med J Islam Repub Iran. 509:119
PMID: 24784220

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